123122-55-4
123122-55-4 结构式
基本信息
中文别名
化合物 T10671 英文别名
UK-79300candoxatril
Candoxatril (UK 79300)
Candoxatril [usan:inn:ban]
4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid
cis-4-[[[1-[(2S)-3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-Methoxyethoxy)Methyl]-3-oxopropyl]cyclopentyl]carbonyl]aMino]cyclohexanecarboxylic Acid
Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-3-[(2,3-dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]-,cis-
物理化学性质
熔点107-109°
比旋光度D -5.8° (c = 1 in methanol)
沸点718.4±60.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)4.84±0.25(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Candoxatril 是中性肽链内切酶 (NEP) 的一个抑制剂。靶点
NEP.
体内研究
While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor.