ChemicalBook--->CAS DataBase List--->123122-55-4

123122-55-4

Request For Quotation
123122-55-4 Structure

123122-55-4 Structure
IdentificationBack Directory
[Name]

CANDOXATRIL
[CAS]

123122-55-4
[Synonyms]

UK-79300
candoxatril
Candoxatril (UK 79300)
Candoxatril [usan:inn:ban]
4α-[[1-[(S)-2-(Indan-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentan-1-yl]carbonylamino]cyclohexane-1α-carboxylic acid
cis-4-[[[1-[(2S)-3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-Methoxyethoxy)Methyl]-3-oxopropyl]cyclopentyl]carbonyl]aMino]cyclohexanecarboxylic Acid
Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-3-[(2,3-dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]-,cis-
[Molecular Formula]

C29H41NO7
[MDL Number]

MFCD00865901
[MOL File]

123122-55-4.mol
[Molecular Weight]

515.64
Chemical PropertiesBack Directory
[Melting point ]

107-109°
[alpha ]

D -5.8° (c = 1 in methanol)
[Boiling point ]

718.4±60.0 °C(Predicted)
[density ]

1.21±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

4.84±0.25(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Neutral endopeptidase inhibitor. Candoxatril is used in treatment of congestive heart failure.
[Definition]

ChEBI: The 2,3-dihydro-1H-inden-5-yl ester of the active enantiomer of candoxatrilat. Candoxatril is an orally active prodrug of candoxatrilat, a potent neutral endopeptidase (NEP, neprilysin) inhibitor used in the treatment of chronic heart fa lure.
[in vivo]

While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor[2].

Spectrum DetailBack Directory
[Spectrum Detail]

CANDOXATRIL(123122-55-4)1HNMR
123122-55-4 suppliers list
Company Name: Chemsky (shanghai) International Co.,Ltd  
Telephone: 021-50135380
Website: www.shchemsky.com
Company Name: Jinan Mingya Medical Technology Co., Ltd.  
Telephone: 0531-85828981
Website: www.chemicalbook.com/ShowSupplierProductsList16067/0_EN.htm
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Telephone: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Career Henan Chemica Co  
Telephone: +86-0371-86658258 +86-13203830695
Website: www.coreychem.com/
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD  
Telephone: 86-571-88216897,88216896 13588875226
Website: www.hzclap.com/en
Company Name: Energy Chemical  
Telephone: 021-58432009 400-005-6266
Website: http://www.energy-chemical.com
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Telephone: 010-60605840
Website: http://www.jm-bio.com/
Company Name: TargetMol Chemicals Inc.  
Telephone: 4008200310 15002144251
Website: https://www.targetmol.cn/
Company Name: Shanghai Yiyan Biotechnology Co. , Ltd.  
Telephone: 021-69985186 13611928337
Website: www.chemicalbook.com/ShowSupplierProductsList1691458/0_EN.htm
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Telephone: 0513-66337626 18051384581
Website: https://www.chemhifuture.com/
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Telephone: 025-85560043 15850508050
Website: http://www.synzest.com
Company Name: Chengdu Peter-like Biotechnology Co., Ltd.  
Telephone: 028-81700200 13308200041
Website: www.weikeqi-biotech.com/
Company Name: Shandong Quadristar Material Technology Co., Ltd  
Telephone: 18173438764
Website: https://www.quadristar-sd.com.cn
Company Name: Shanghai meikai technology co., ltd  
Telephone: 021-68689288 15300790979
Website: www.mkbio.com.cn/
Company Name: Shanghai Amole Biotechnology Co., Ltd.  
Telephone: 13370042665 18916960931
Website: www.amole.com.cn/
Company Name: Changzhou Extraordinary Pharmatech co., LTD.  
Telephone: 0519-82111935 15195055733
Website: http://www.feifanchem.com
Company Name: Absin Bioscience Inc.  
Telephone: 13761418683
Website: www.absin.cn/
Company Name: Qingdao Haizhi Weiyuan Biotechnology Co., Ltd.  
Telephone: 18317699790 18317699790
Website:
Tags:123122-55-4 Related Product Information
123122-55-4 76721-89-6 92175-57-0 277333-45-6 3918-87-4 135038-59-4