1246960-27-9

中文名称依格列汀

英文名称 Evogliptin hydrochloride

CAS 1246960-27-9

分子式 C19H27ClF3N3O3

分子量 437.89

MOL 文件 1246960-27-9.mol

1246960-27-9 结构式

基本信息应用领域常见问题列表

基本信息

中文别名

化合物 T31732

英文别名

DA1229
DA 1229
DA-1229
Evogliptin HCl
Evogliptin hydrochloride

应用领域

用途一

Evogliptin, also known as DA-1229, is a potent and selective DPP4 inhibitor (dipeptidyl peptidase 4 inhibitor). Evogliptin improves insulin resistance and delays the onset of diabetes. Evogliptin improves the insulin sensitivity in HF mice and delays the onset of diabetes in young db/db mice. DA-1229 monotherapy (5 mg for 12 weeks) improved HbA1c, fasting plasma glucose level, OGTT results and β-cell function. This drug was well tolerated in Korean subjects with type 2 diabetes mellitus.

常见问题列表

概述

依格列汀是一种口服有效的 DPP4 抑制剂，在小鼠模型中具有显著而持久的降糖效果。Evogliptin hydrochloride 还可通过诱导自噬来抑制肝细胞的炎症和纤维化信号的产生。Evogliptin hydrochloride 可用于 2 型糖尿病、骨质疏松症，肾功能损害以及慢性肝脏炎症的研究。