132836-42-1

中文名称 1,2,3,4-四氢-1-(1-萘基甲基)-6,7-异喹啉二醇氢溴酸盐

英文名称 YS 49

CAS 132836-42-1

分子式 C20H20BrNO2

分子量 386.282

MOL 文件 132836-42-1.mol

更新日期 2023/03/20 15:41:21

132836-42-1 结构式

基本信息物理化学性质安全数据图谱信息常见问题列表

基本信息

中文别名

1,2,3,4-四氢-1-(1-萘基甲基)-6,7-异喹啉二醇氢溴酸盐

英文别名

YS 49
CS-884
YS 49
YS49
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate

所属类别

生物化工：激动剂抑制剂

物理化学性质

储存条件2-8°C

溶解度H2O：>10mg/mL

形态固体

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302

危险品标志Xn,N

危险类别码22-50

安全说明61

危险品运输编号UN 3077 9 / PGIII

WGK Germany3

图谱信息

1,2,3,4-四氢-1-(1-萘基甲基)-6,7-异喹啉二醇氢溴酸盐(132836-42-1)核磁图(¹HNMR)

常见问题列表

生物活性

YS-49 是 PI3K/Akt (RhoA 的下游靶标) 的激活剂，可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。YS-49 能通过诱导血红素加氧酶 (HO-1) 来抑制血管紧张素 II (Ang II) 刺激 VSMC 细胞的增殖。YS-49 是异喹啉化合物生物碱，因能激活心脏 β-adrenoceptors 而具有强烈的正性肌力作用。

体外研究

YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC ₅₀ values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.

Cell Viability Assay

Cell Line:	RAVSMC and RAW 264.7 cells
Concentration:	10 μΜ, 30 μΜ and 100 μΜ (RAVSMC cells); 1 μΜ, 10 μΜ and 100 μM (RAW 264.7 cells)
Incubation Time:	18 hours
Result:	Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC ₅₀ values of 22 and 30 μM, respectively.

Western Blot Analysis

Cell Line:	RAVSMC and RAW 264.7 cells
Concentration:	10 μΜ, 30 μΜ and 100 μΜ
Incubation Time:	18 hours
Result:	Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ.

体内研究

YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.

Animal Model:	Male Sprague Dawley rats (250-300 g)
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 8 hours
Result:	Serum NOx levels were significantly reduced.