1374601-40-7
中文名称
2-苯甲酰胺基-1-(3-苯丙基)-1H-苯并[D]咪唑-5-羧酸甲酯
英文名称
BRD4770
CAS
1374601-40-7
分子式
C25H23N3O3
更新日期
2024/04/27 22:04:59
分子量
413.47
MOL 文件
1374601-40-7.mol
1374601-40-7 结构式
基本信息
中文别名
化合物BRD4770EHMT2抑制剂(BRD4770)
2-苯甲酰胺基-1-(3-苯丙基)-1H-苯并[D]咪唑-5-羧酸甲酯
英文别名
CS-1814BRD4770
BRD4770 USP/EP/BP
BRD-4770
BRD 4770
Methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate
methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate
Methyl-2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate
2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester
methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate BRD4770
1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-, methyl ester
所属类别
生物化工：Histone Methyltransferase 抑制剂物理化学性质
密度1.21±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO：可溶5mg/mL，澄清（加热）
酸度系数(pKa)12.12±0.43(Predicted)
形态粉末
颜色白色至米色
CAS 数据库1374601-40-7
常见问题列表
生物活性
BRD4770是一种histone methyltransferase G9a抑制剂，其IC50为6.3 μM，并且会诱导细胞死亡。体外研究
BRD4770 reduces cellular levels of di- and trimethylated H3K9 via inhibition of G9a, induces senescence, and inhibits both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. The combination of gossypol and BRD4770 increases LC3-II levels and the autophagosome number, and thus acts in synergy to induce cell death in PANC-1 cells.