| Identification | Back Directory | [Name]
BRD4770 | [CAS]
1374601-40-7 | [Synonyms]
BRD4770
CS-1814
BRD4770 USP/EP/BP
BRD-4770; BRD 4770
Methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate
methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate
Methyl-2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate
2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester
methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate BRD4770
1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-, methyl ester | [EINECS(EC#)]
802-776-3 | [Molecular Formula]
C25H23N3O3 | [MDL Number]
MFCD23143627 | [MOL File]
1374601-40-7.mol | [Molecular Weight]
413.47 |
| Chemical Properties | Back Directory | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
12.12±0.43(Predicted) | [color ]
white to beige | [InChIKey]
UCGWYCMPZXDHNR-UHFFFAOYSA-N | [SMILES]
C1(NC(=O)C2=CC=CC=C2)N(CCCC2=CC=CC=C2)C2=CC=C(C(OC)=O)C=C2N=1 | [CAS DataBase Reference]
1374601-40-7 |
| Hazard Information | Back Directory | [Uses]
BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 μM). Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis. It also blocks both anchorage-dependent and –independent proliferation of PANC-1 cells.[Cayman Chemical] | [Definition]
ChEBI:2-benzamido-1-(3-phenylpropyl)-5-benzimidazolecarboxylic acid methyl ester is a member of benzimidazoles. | [Biochem/physiol Actions]
BRD4770 is a selective inhibitor of the histone methyltransferase G9a. BRD4770 blocks lysine residue 9 methylation of histone H3 without inducing apoptosis. In PANC-1 cells, BRD4770 activates the ataxia telangiectasia mutated (ATM) pathway, induces senescence and inhibits anchorage-dependent and -independent growth. | [IC 50]
EHMT2/G9a/KMT1C | [storage]
Store at -20°C |
|
| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
D&C Chemicals
|
| Telephone: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
|