1374601-40-7

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1374601-40-7 Structure

Identification	Back Directory
[Name] BRD4770
[CAS] 1374601-40-7
[Synonyms] BRD4770 CS-1814 BRD4770 USP/EP/BP BRD-4770; BRD 4770 Methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate Methyl-2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate 2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate BRD4770 1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-, methyl ester
[EINECS(EC#)] 802-776-3
[Molecular Formula] C25H23N3O3
[MDL Number] MFCD23143627
[MOL File] 1374601-40-7.mol
[Molecular Weight] 413.47

Chemical Properties	Back Directory
[density ] 1.21±0.1 g/cm3(Predicted)
[storage temp. ] 2-8°C
[solubility ] DMSO: soluble5mg/mL, clear (warmed)
[form ] powder
[pka] 12.12±0.43(Predicted)
[color ] white to beige
[CAS DataBase Reference] 1374601-40-7

Hazard Information	Back Directory
[Uses] BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 μM). Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis. It also blocks both anchorage-dependent and –independent proliferation of PANC-1 cells.[Cayman Chemical]
[Definition] ChEBI:2-benzamido-1-(3-phenylpropyl)-5-benzimidazolecarboxylic acid methyl ester is a member of benzimidazoles.
[Biochem/physiol Actions] BRD4770 is a selective inhibitor of the histone methyltransferase G9a. BRD4770 blocks lysine residue 9 methylation of histone H3 without inducing apoptosis. In PANC-1 cells, BRD4770 activates the ataxia telangiectasia mutated (ATM) pathway, induces senescence and inhibits anchorage-dependent and -independent growth.
[IC 50] EHMT2/G9a/KMT1C
[storage] Store at -20°C

Spectrum Detail	Back Directory
[Spectrum Detail] BRD4770(1374601-40-7)¹HNMR

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