1448-36-8
1448-36-8 结构式
基本信息
胆酸甲酯, 98+%
5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA, 12-ALPHA-TRIOL METHYL ESTER
CHOLIC ACID METHYL ESTER
METHYL 4-(3,7,12-TRIHYDROXY-10,13-DIMETHYLPERHYDROCYCLOPENTA[A]PHENANTHREN-17-YL)PENTANOATE
METHYL CHOLATE
Methyl 4-(3,7,12-trihydroxy-10,13-dimethylperhydrocyclopenta[a]phenanthren-17-yl)pen
CHOLIC ACID METHYL ESTER(P)
Methyl cholate, 98+%
3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid methyl ester
3α,7α,12α-Triol-5β-24-cholanoic acid methyl ester
Cholic acid methyl
物理化学性质
制备方法
67-56-1
81-25-4
1448-36-8
向胆酸(2.0g, 4.9mmol)的甲苯/甲醇(30ml, V/V=2:1)混合溶液中加入三甲基硅基重氮甲烷(3.67ml, 7.34mmol)，于20℃下搅拌反应2小时。通过薄层色谱(TLC, 展开剂比例为甲醇/二氯甲烷=1:10)监测反应进程，确认胆酸完全消耗并有新斑点生成。反应完成后，将反应混合物浓缩，得到(R)-甲基 4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-三羟基-10,13-二甲基十六氢-1H-环戊[a]菲蒽-17-基)戊酸酯(2.08g, 产率100%)，为白色泡沫状固体。其氢核磁共振谱(400MHz, CDCl3)数据如下：δ 3.98(m, 1H, C12-H), 3.85(m, 1H, C7-H), 3.45(m, 1H, C3-H), 3.66(s, 3H, OCH3), 0.98(d, 3H, 21-Me), 0.89(s, 3H, 19-Me), 0.69(s, 3H, 18-Me)。
参考文献：
[1] Drug Metabolism and Disposition, 2017, vol. 45, # 7, p. 721 - 733
[2] Patent: WO2009/146218, 2009, A2. Location in patent: Page/Page column 141
[3] Tetrahedron Letters, 2010, vol. 51, # 1, p. 93 - 95
[4] Steroids, 2010, vol. 75, # 10, p. 701 - 709
[5] Tetrahedron Letters, 2011, vol. 52, # 52, p. 7128 - 7131
知名试剂公司产品信息
Methyl cholate, 98+%(1448-36-8)
Methyl Cholate,>96.0%(GC)(1448-36-8)