1449240-68-9

中文名称 3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐

英文名称 K145 (hydrochloride)

CAS 1449240-68-9

分子式 C18H25ClN2O3S

分子量 384.921

MOL 文件 1449240-68-9.mol

更新日期 2023/03/20 15:41:25

1449240-68-9 结构式

基本信息物理化学性质安全数据图谱信息 3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐价格(试剂级) 常见问题列表

基本信息

中文别名

SPHK2抑制剂(K145盐酸盐)
3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐

英文别名

K145(HCl)
SphK2 inhibitor
K14 (hydrochloride)
K145 (hydrochloride)
K145 hydrochloride >=98% (HPLC)
SPHK2 INHIBITOR
K 145 HYDROCHLORIDE
K-145 HYDROCHLORIDE
3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione hydrochloride
3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-2,4-thiazolidinedione hydrochloride (1:1)

所属类别

生物化工：激动剂抑制剂

物理化学性质

储存条件2-8°C

溶解度在DMSO中的溶解度为20mg/mL，澄清

形态粉末

颜色白色至米色

安全数据

WGK Germany3

图谱信息

3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐(1449240-68-9)核磁图(¹HNMR)

3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-15779A	3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐 K145 hydrochloride	1449240-68-9	5mg	418元
2025/05/22	HY-15779A	3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐 K145 hydrochloride	1449240-68-9	10mM * 1mLin DMSO	459元
2025/05/22	HY-15779A	3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐 K145 hydrochloride	1449240-68-9	10mg	585元

常见问题列表

生物活性

K145 hydrochloride 是一种选择性的，具有底物竞争性和口服活性的 SphK2 抑制剂，IC50 为 4.3 µM，Ki 为 6.4 µM。K145 hydrochloride 对 SphK1 和其他蛋白激酶没有活性。K145 hydrochloride 可诱导细胞凋亡，并具有强大的抗肿瘤活性。

靶点

IC50: 4.3 µM (SphK2)
Ki: 6.4 µM (SphK2)

体外研究

K145 (0-10 µM; 24-72 hours; U937 cells) treatment significantly inhibits the growth of U937 cells in a concentration-dependent manner.
K145 (10 µM; 24 hours; U937 cells) treatment significantly induces apoptosis in U937 cells.
K145 (4-8 µM; 3 hours; U937 cells) treatment decreases the phosphorylation of ERK and Akt.
Treatment with K145 (10 µM) causes a decrease of total cellular S1P without significant effects on ceramide levels.

Cell Viability Assay

Cell Line:	U937 cells
Concentration:	0 µM, 4 µM, 6 µM, 8 µM, 10 µM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Significantly inhibited the growth of U937 cells in a concentration-dependent manner.

Apoptosis Analysis

Cell Line:	U937 cells
Concentration:	10 µM
Incubation Time:	24 hours
Result:	Significantly induced apoptosis in U937 cells.

Western Blot Analysis

Cell Line:	U937 cells
Concentration:	4 µM, 8 µM
Incubation Time:	3 hours
Result:	Phosphorylated ERK and Akt were decreased.

体内研究

K145 (50 mg/kg; oral gavage; daily; for 15 days; BALB/c-nu mice) treatment significantly inhibits the growth of U937 tumors in nude mice.

Animal Model:	BALB/c-nu mice injected with U937 cells
Dosage:	50 mg/kg
Administration:	Oral gavage; daily; for 15 days
Result:	Inhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed.