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1449240-68-9

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1449240-68-9 Structure

1449240-68-9 Structure
IdentificationBack Directory
[Name]

K145 (hydrochloride)
[CAS]

1449240-68-9
[Synonyms]

K145(HCl)
SphK2 inhibitor
K14 (hydrochloride)
K145 (hydrochloride)
K145 hydrochloride >=98% (HPLC)
SPHK2 INHIBITOR;K 145 HYDROCHLORIDE;K-145 HYDROCHLORIDE
3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione hydrochloride
3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-2,4-thiazolidinedione hydrochloride (1:1)
[Molecular Formula]

C18H25ClN2O3S
[MDL Number]

MFCD28160629
[MOL File]

1449240-68-9.mol
[Molecular Weight]

384.921
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble20mg/mL, clear
[form ]

powder
[color ]

white to beige
[InChI]

1S/C18H24N2O3S.ClH/c1-2-3-13-23-15-9-7-14(8-10-15)5-4-6-16-17(21)20(12-11-19)18(22)24-16;/h6-10H,2-5,11-13,19H2,1H3;1H/b16-6-;
[InChIKey]

HADFDMGQKBGVAV-NKBLJONXSA-N
[SMILES]

S1\C(=C/CCc2ccc(cc2)OCCCC)\C(=O)N(C1=O)CCN.Cl
Safety DataBack Directory
[Symbol(GHS) ]

Corrosion (GHS05)Health Hazard (GHS08)
GHS05,GHS08
[Signal word ]

Danger
[Hazard statements ]

H315-H318-H334-H317-H341-H361-H370-H413
[Precautionary statements ]

P201-P202-P260-P264-P270-P272-P273-P280-P284-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P362+P364-P333+P313-P342+P311-P363-P405-P501
[WGK Germany ]

3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

K145 hydrochloride has been used in the analysis of apoptosis.
[General Description]

K145 hydrochloride (3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is an analog of sphingosine.
[Biochem/physiol Actions]

It has the ability to prevent leukemia cell growth in vitro.
[in vivo]

K145 (50 mg/kg; oral gavage; daily; for 15 days; BALB/c-nu mice) treatment significantly inhibits the growth of U937 tumors in nude mice[1].

Animal Model:BALB/c-nu mice injected with U937 cells[1]
Dosage:50 mg/kg
Administration:Oral gavage; daily; for 15 days
Result:Inhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed.
[IC 50]

SphK2
Spectrum DetailBack Directory
[Spectrum Detail]

K145 (hydrochloride)(1449240-68-9)1HNMR
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