145317-11-9
中文名称
BISINDOLYLMALEIMIDE X HYDROCHLORIDE (BIM-X HYDROCHLORIDE)
英文名称
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
CAS
145317-11-9
分子式
C26H22N4O3
分子量
438.478
MOL 文件
145317-11-9.mol
145317-11-9 结构式
基本信息
中文别名
化合物 T10550化合物 T10550,10 MM DMSO 溶液
化合物 BISINDOLYLMALEIMIDE X HYDROCHLORIDE
BISINDOLYLMALEIMIDE X HYDROCHLORIDE (RO 31-8425),PKC抑制剂
3-(8-(氨基甲基)-6,7,8,9-四氢吡啶并[1,2-A]吲哚-10-基)-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮盐酸盐
3-(8-(氨基甲基)-6,7,8,9-四氢吡啶并[1,2-A]吲哚-10-基)-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮 X盐酸盐
英文别名
BIM XBIM-X hydrochloride
Ro 31-8425 Ro 31-8425
Bisindoylmaleimide X HCl
BIM X
RO 31-8425RO 31-8425
Bisindoylmaleimide X hydrochloride ≥95%
Bisindoylmaleimide X (Ro 31-8425)
BISINDOLYLMALEIMIDE X HYDROCHLORIDE (BIM-X HYDROCHLORIDE)
3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
物理化学性质
储存条件Inert atmosphere,2-8°C
溶解度Soluble in DMSO (up to 10 mg/ml)
形态红色固体。
颜色Red
生物来源synthetic (organic)
稳定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
常见问题列表
生物活性
Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) 是一种有效的，选择性的蛋白激酶 C (PKC) 抑制剂。Bisindolylmaleimide X hydrochloride 也是一种有效的细胞周期蛋白依赖性激酶 2 (CDK2) 拮抗剂，IC50 为 200 nM。靶点
|
CDK2 200 nM (IC 50 ) |
PKC
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体外研究
Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride; Ro31-8425 hydrochloride) derivatives acts as an useful tool to compare inhibitor potencies and selectivities for a target of interest.