1453221-07-2
中文名称
(S)-N-((6S,9S,12S,15S,18S,21S,24S,27S,30S,33S)-12-((1H-吲哚-3-基)甲基)-1-氨基-15,30-二((S)-仲丁基)-6-氨基甲酰基-9,18-双(3-胍基丙基)-1-亚氨基-21,27-二异丙基-24,35-二甲基-8,11,14,17,20,23,26,29,32-九氧代-2,7,10,13,16,19,22,25,28,31-十氮杂三十六烷-33-基)-2-((S)-2-氨基-3-甲基丁酰胺基)-5-胍基戊酰胺
英文名称
(S)-N-((6S,9S,12S,15S,18S,21S,24S,27S,30S,33S)-12-((1H-Indol-3-yl)methyl)-1-amino-15,30-di((S)-sec-butyl)-6-carbamoyl-9,18-bis(3-guanidinopropyl)-1-imino-21,27-diisopropyl-24,35-dimethyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazahexatriacontan-33-yl)-2-((S)-2-amino-3-methylbutanamido)-5-guanidinopentanamide
CAS
1453221-07-2
分子式
C71H126N26O12
分子量
1535.93
MOL 文件
1453221-07-2.mol
1453221-07-2 结构式
基本信息
中文别名
(S)-N-((6S,9S,12S,15S,18S,21S,24S,27S,30S,33S)-12-((1H-吲哚-3-基)甲基)-1-氨基-15,30-二((S)-仲丁基)-6-氨基甲酰基-9,18-双(3-胍基丙基)-1-亚氨基-21,27-二异丙基-24,35-二甲基-8,11,14,17,20,23,26,29,32-九氧代-2,7,10,13,16,19,22,25,28,31-十氮杂三十六烷-33-基)-2-((S)-2-氨基-3-甲基丁酰胺基)-5-胍基戊酰胺 英文别名
L-Argininamide, L-valyl-L-arginyl-L-leucyl-L-isoleucyl-L-valyl-L-alanyl-L-valyl-L-arginyl-L-isoleucyl-L-tryptophyl-L-arginyl-(S)-N-((6S,9S,12S,15S,18S,21S,24S,27S,30S,33S)-12-((1H-Indol-3-yl)methyl)-1-amino-15,30-di((S)-sec-butyl)-6-carbamoyl-9,18-bis(3-guanidinopropyl)-1-imino-21,27-diisopropyl-24,35-dimethyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazahexatriacontan-33-yl)-2-((S)-2-amino-3-methylbutanamido)-5-guanidinopentanamide
物理化学性质
密度1.384±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
酸度系数(pKa)13.282±0.46(predicted)
序列Val-Arg-Leu-Ile-Val-Ala-Val-Arg-Ile-Trp-Arg-Arg-NH2
常见问题列表
概述
(S)-N-((6S,9S,12S,15S,18S,21S,24S,27S,30S,33S)-12-((1H-吲哚-3-基)甲基)-1-氨基-15,30-二((S)-仲丁基)-6-氨基甲酰基-9,18-双(3-胍基丙基)-1-亚氨基-21,27-二异丙基-24,35-二甲基-8,11,14,17,20,23,26,29,32-九氧代-2,7,10,13,16,19,22,25,28,31-十氮杂三十六烷-33-基)-2-((S)-2-氨基-3-甲基丁酰胺基)-5-胍基戊酰胺 是一种先天防御调节剂偶联物，对MRSA USA300 LAC、MRSA SAP 0017和S. epidermidis ATCC14990的MIC为16 μg/mL。IDR-1018可用于合成V-IDR1018(万古霉素-先天防御调节剂偶联物)。