1477-57-2
中文名称
N,N'-八亚甲基双二氯乙酰胺
英文名称
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
CAS
1477-57-2
分子式
C12H20Cl4N2O2
分子量
366.11
MOL 文件
1477-57-2.mol
更新日期
2023/06/12 20:30:50
1477-57-2 结构式
基本信息
中文别名
佛替来辛N,N'-八亚甲基双二氯乙酰胺
N,N′-八亚甲基双(2,2-二氯乙酰胺)
N,N′-双(二氯乙酰基)-1,8-八亚甲基二胺
N,N'-1,8-辛二基双[2,2-二氯]乙酰胺
英文别名
r-010-tkwin18441
win18446
win18,446
NSC 59354
bisdiamine
FERTILYSIN
bis-diamine
Fertilysine
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
所属类别
化学试剂：酰胺物理化学性质
熔点118-120 °C
熔点118-120 °C
沸点530℃
密度0.726
密度0.726
折射率1.6200 (estimate)
闪点275℃
储存条件2-8°C
储存条件Inert atmosphere,2-8°C
溶解度可溶于丙酮（非常少量）、DMSO（少量）、甲醇（少量、加热、超声处理)
酸度系数(pKa)12.28±0.46(Predicted)
形态固体
颜色白色至灰白色
CAS 数据库1477-57-2
安全数据
警示词警告
危险性描述H312+H332-H351
危险品标志Xn
危险类别码20/21/22-40
安全说明24/25-45-36
毒性LD50 orally in mice: >16000 mg/kg (Coulston)
N,N'-八亚甲基双二氯乙酰胺价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-W011094 | N,N'-八亚甲基双二氯乙酰胺 Win 18446 | 1477-57-2 | 50mg | 1000元 |
| 2024/01/25 | HY-W011094 | N,N'-八亚甲基双二氯乙酰胺 Win 18446 | 1477-57-2 | 10mM * 1mLin DMSO | 1100元 |
常见问题列表
生物活性
Win 18446 是具有口服活性的睾丸特异性的酶 ALDH1a2 的抑制剂，其 IC50 值为 0.3 μM。Win 18446 可逆的抑制多个物种的精子形成，抑制睾丸内视黄醇 (HY-B1342) 合成视黄酸 (HY-14649)。体外研究
WIN 18446 (1 μM, 24 h) is able to suppress Stra8 expression in whole-testes cultures that contained both germ and somatic cells.
RT-PCR
| Cell Line: | Testes were collected from 2-dpp mice. |
| Concentration: | 1 μM. |
| Incubation Time: | 24 h. |
| Result: |
Results in a VAD-like phenotype in the testis.
Alone or in combination with ROL significantly reduced Stra8 expression. |
体内研究
Win 18446 (200 mg/kg, Orally for 4, 8, and 16 weeks) significantly reduces intratesticular concentrations of retinoic acid, severely impaired spermatogenesis, and caused infertility.
| Animal Model: | Six-month-old male New Zealand white rabbits. |
| Dosage: | 200 mg/kg. |
| Administration: | Orally for 4, 8, and 16 weeks. |
| Result: |
Resulted in marked suppression of testicular weight over time.
Dramatically suppressed spermatogenesis. Significantly reduces intratesticular concentrations of retinoic acid and Stra8 expression and very severely suppresses spermatogenesis and fertility. |