149400-88-4

中文名称 SARDOMOZIDE

英文名称 4-amidinoindan-1-one 2'-amidinohydrazone

CAS 149400-88-4

分子式 C11H14N6

分子量 230.27

MOL 文件 149400-88-4.mol

149400-88-4 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T12833
2-(4-甲脒基-2,3-二氢-1H-茚-1-亚基)肼甲脒

英文别名

SAM 486A
CGP 48664
SardoMozide
4-amidinoindan-1-one 2'-amidinohydrazone
(E)-2-(4-carbaMiMidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinec
2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide
(E)-2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide
Hydrazinecarboximidamide, 2-[4-(aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]-

物理化学性质

沸点438.8±55.0 °C(Predicted)

密度1.54±0.1 g/cm3(Predicted)

储存条件Keep in dark place,Sealed in dry,2-8°C

溶解度溶于二甲基亚砜

酸度系数(pKa)11.54±0.20(Predicted)

常见问题列表

生物活性

Sardomozide 是一种 S-腺苷甲硫氨酸脱羧酶 (SAMDC) 抑制剂，其 IC50 值为 5 nM。

靶点

IC50: 5 nM (SAMDC)

体外研究

Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC ₅₀ of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells.