15291-76-6
15291-76-6 结构式
基本信息
白果苦内酯 C
银杏内酯C(标准品)
GINKGOLIDE C 银杏内酯C
白果苦内酯C,1Β,7Β-二羟基银杏内酯A
银杏内酯C(白果苦内酯C,1Β,7Β-二羟基银杏内酯A)
CGinkgolid
GINKGOLIDE C
Gingkolide C
1,7-DIHYDROXY-GINKGOLIDE A
GinkgolideA,1,7-dihydroxy-, (1α,7β)-
Ginkgolide C,1,7-Dihydroxy-ginkgolide A
(1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
物理化学性质
常见问题列表
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AMPK
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MMP-9
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Human Endogenous Metabolite
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Sirtuin
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Ginkgolide C (3-100 μM) has no significant effect on 3T3-L1 cell viability, but suppresses adipogenesis in 3T3-L1 cells followling 24 h treatment. Ginkgolide C (10-100 μM) significantly suppresses lipid accumulation compared with the control group and also significantly promotes glycerol release in 3T3-L1 adipocytes. Ginkgolide C suppresses PPAR-α and PPAR-γ expression and decreases C/EBPα, C/EBPβ, and SREBP-1c expression in differentiated 3T3-L1 adipocytes. In addition, Ginkgolide C (3-100 μM) suppress adipogenesis-related protein (FAS, LPL, and aP2) and mRNA expression in a dose-dependent manner in differentiated 3T3-L1 adipocytes. Ginkgolide C (3-100 μM) also significantly promotes Sirt1 production and increases phosphorylation of AMPKα and ACC-1 in a concentration-dependent manner. Ginkgolide C (1, 10, 50, 100, 500 mM) significantly reduces the collagen (10 mg/mL)-stimulated rat platelet aggregation in a dose-dependent manner. Ginkgolide C (50, 100 mM) causes pro-MMP-9 (92-kDa) to form an activated MMP-9 (86-kDa) in collagen-stimulated platelets.