| Identification | Back Directory | [Name]
Ginkgolide C | [CAS]
15291-76-6 | [Synonyms]
bn52022
CGinkgolid
Gingkolide C
GINKGOLIDE C
1,7-DIHYDROXY-GINKGOLIDE A
GinkgolideA,1,7-dihydroxy-, (1α,7β)-
Ginkgolide C,1,7-Dihydroxy-ginkgolide A
(1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione | [Molecular Formula]
C20H24O11 | [MDL Number]
MFCD06642603 | [MOL File]
15291-76-6.mol | [Molecular Weight]
440.4 |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
>3000 (dec) | [alpha ]
D24 -14.7° (c = 1 in ethanol) | [Boiling point ]
813.8±65.0 °C(Predicted) | [density ]
1.72±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Heated) | [form ]
neat | [pka]
10.88±0.70(Predicted) | [color ]
White to Off-White | [InChIKey]
AMOGMTLMADGEOQ-WCHJOOGENA-N | [LogP]
1.719 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Uses]
Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists | [Uses]
Reference compound for PAF receptors in biological systems. | [Description]
Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM).1 Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.2 | [IC 50]
AMPK; MMP-9; Sirtuin | [References]
[1] PIERRE BRAQUET. Recent progress in ginkgolide research[J]. Medicinal Research Reviews, 1991, 11 3: 295-355. DOI: 10.1002/med.2610110303
[2] CHIAN-JIUN LIOU. Ginkgolide C Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway.[J]. Evidence-based Complementary and Alternative Medicine, 2015: 298635. DOI: 10.1155/2015/298635 |
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| Company Name: |
cuicheng bio Gold
|
| Telephone: |
13186333400 |
| Website: |
www.cuichengbio.com/ |
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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