1553-56-6
中文名称
-胆烷酸
英文名称
3-Oxo-5beta-cholanoic Acid
CAS
1553-56-6
分子式
C24H38O3
分子量
374.56
MOL 文件
1553-56-6.mol
更新日期
2024/05/08 09:57:55
1553-56-6 结构式
基本信息
中文别名
-胆烷酸脱氢石胆酸
3-氧代-5&Β
3-酮-5B-胆烷酸
化合物 T13502
3-氧代-5Β-胆酸
3-氧代-5Β-胆烷酸
3-氧代-5&BETA
3-恶唑烷-24-油酸
3-氧代-5BETA-胆酸
英文别名
3-oxocholanicacid3-KETOCHOLANIC ACID
3-oxolithocholicacid
3-ketolithocholicacid
3-Oxo-5β-cholanic acid
5β-CHOLANIC acid-3-ONE
5-B-CHOLANIC ACID-3-ONE
DEHYDROLITHOCHOLIC ACID
3-oxocholan-24-oic acid
5β-Cholanic acid-3-one
物理化学性质
熔点140-141 °C
沸点509.3±23.0 °C(Predicted)
密度1.069±0.06 g/cm3(Predicted)
储存条件Refrigerator
溶解度可溶于氯仿（少许）、甲醇（少许）
酸度系数(pKa)4.76±0.10(Predicted)
形态固体
颜色白色至淡黄色
CAS 数据库1553-56-6
常见问题列表
生物活性
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid)，胆汁酸代谢产物，通过直接与关键转录因子RORγt (Kd=1.13 μM) 结合抑制 TH17 细胞分化。体外研究
Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity.
体内研究
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells.
| Animal Model: | B6 Jax mice (with a faecal slurry containing SFB) |
| Dosage: | 0.3% (w/w) |
| Administration: | Gavaged; for 1 week |
| Result: | Significantly reduced the percentage of ileal TH17 cells. |