161401-82-7
中文名称
Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE
英文名称
Z-Vad-fmk, non-methylated
CAS
161401-82-7
分子式
C21H28FN3O7
分子量
453.46
MOL 文件
161401-82-7.mol
更新日期
2024/11/11 14:51:00

基本信息
中文别名
PAN-CASPASE抑制剂 英文别名
Z-VAD-FMK, Free AcidZ-VAD-FMK (Caspase Inhibitor VI)
Z-VAD(OH)-FMK (Caspase Inhibitor VI)
Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE
Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone
Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem
L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-
L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-, (S)-
L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]- (9ci)
所属类别
生物化工:激动剂抑制剂物理化学性质
沸点758.0±60.0 °C(Predicted)
密度1.260±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM)
酸度系数(pKa)3.91±0.19(Predicted)
形态类白色固体
颜色White to light yellow
常见问题列表
生物活性
Z-VAD-FMK (Z-VAD(OH)-FMK) 是一种 pan caspase 抑制剂。Z-VAD-FMK 不抑制泛素 C 末端水解酶 L1 (UCHL1) 活性,即使浓度高达 440 μM。靶点
Caspase
|
体外研究
Z-VAD-FMK (40 μM) reverses the apoptotic effect exerted by total saponin of Solanum lyratum Thunb (TSSLT) in Hela cells. HeLa cells are pretreated with Z-VAD-FMK (40 μM) for 30 min and exposed to TSSLT (6 μg/mL) for 48 h.
Cell Viability Assay
Cell Line: | HeLa cells |
Concentration: | 40 μM |
Incubation Time: | Prtreated for 30 minutes |
Result: | Prevented TSSLT-induced cell death. More than 80% cell survival was observed. |