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16220-07-8

中文名称 异胡芦巴核苷
英文名称 ALLOPURINOL RIBOSIDE
CAS 16220-07-8
分子式 C10H12N4O5
分子量 268.23
MOL 文件 16220-07-8.mol
更新日期 2024/12/03 15:40:34
16220-07-8 结构式 16220-07-8 结构式

基本信息

中文别名
异胡芦巴核苷
别嘌呤醇核糖苷
ALLOPURINOL 核苷
英文别名
8-AZA-7-DEAZAINOSINE
ALLOPURINOL RIBOSIDE
Allopurinol ribonucleoside
Allopurinol-1-ribonucleoside
1-BETA-D-RIBOFURANOSYLPYRAZOLO[3,4-D]PYRIMIDIN-4-ONE
1-β-d-ribofuranosyl-1h-pyrazolo[3,4-d]pyrimidine-4-one
1-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE-4-ONE
1,5-Dihydro-1-β-D-ribofuranosyl-4H-pyrazolo[3,4-d]pyrimidin-4-one
4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-D-ribofuranosyl-
1-[(2S,3S,4R,5R)-3,4,5,6-tetrahydroxyoxan-2-yl]-2H-pyrazolo[4,5-e]pyrimidin-4-one

物理化学性质

沸点715.0±60.0 °C(Predicted)
密度2.08±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO:5.0(Max Conc. mg/mL);18.64(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);18.64(Max Conc. mM)
酸度系数(pKa)8.65±0.10(Predicted)
形态A solid
颜色White to off-white

安全数据

WGK Germany3
异胡芦巴核苷价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2025/02/08HY-101397异胡芦巴核苷
Allopurinol riboside
16220-07-81 mg300元
2025/02/08HY-101397异胡芦巴核苷
Allopurinol riboside
16220-07-85mg600元
2025/02/08HY-101397异胡芦巴核苷
Allopurinol riboside
16220-07-810 mg900元

常见问题列表

生物活性
Allopurinol riboside是别嘌呤醇的代谢物,能有效地抑制寄生虫。
靶点

Human Endogenous Metabolite

体外研究

Allopurinol-riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a K i of 277 μM. Lymphocyte blastogensis induced by PHA and Con A is significantly suppressed by allopurinol-riboside in a concentration-dependent manner. When LPS is used as a mitogen, the inhibition of allopurinol-ribosideon lymphocyte proliferation is less marked. Humoral immunity is not suppressed by allopurinol-riboside. Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Allopurinol riboside is effective against parasites, because a series of enzymes (analogous to those that mediate purine salvage in humans) convert it into 4-aminopyrazolopyrimidine ribonucleoside triphosphate, a cytotoxic product. Allopurinol riboside is selectively toxic, because it is not metabolized by the corresponding enzymes in humans.

体内研究

Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 hours, and steady-state concentrations in the therapeutic range. After oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma.

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