17817-31-1

中文名称 4',6,7-三羟异黄酮

英文名称 6,7,4'-Trihydroxyisoflavone

CAS 17817-31-1

分子式 C15H10O5

MDL 编号 MFCD00016953

分子量 270.24

MOL 文件 17817-31-1.mol

更新日期 2024/04/24 17:29:45

17817-31-1 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

4',6',7'-三羟异黄酮
4',6,7-三羟基异黄酮

英文别名

4',6,7-TRIHYDROXYISOFLAVONE
6,7,4'-TRIHYDROXYISOFLAVONE
DEMETHYLTEXASIN
TRIHYDROXYISOFLAVONE, 4',6,7-
TRIHYDROXYISOFLAVONE, 4',6,7-(RG)
6,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one

所属类别

生物化工：提取物

物理化学性质

熔点>280℃

沸点587.1±50.0 °C(Predicted)

密度1.548±0.06 g/cm3(Predicted)

储存条件2-8°C

溶解度溶于二甲基甲酰胺

酸度系数(pKa)6.85±0.20(Predicted)

形态粉末晶体

颜色淡黄色至棕色至深绿色

LogP2.170 (est)

CAS 数据库17817-31-1(CAS DataBase Reference)

安全数据

危险性符号(GHS)

GHS05,GHS06,GHS08,GHS09

警示词危险

危险性描述H330-H302-H314-H370-H372-H373-H341-H350-H411-H290

防范说明P501-P273-P260-P270-P202-P234-P201-P271-P264-P280-P284-P390-P391-P308+P311-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P406-P405

安全说明S22-S24/25

WGK Germany3

F10

海关编码2914.69.9000

常见问题列表

生物活性

Desmethylglycitein (4',6,7-Trihydroxyisoflavone)，大豆苷元的代谢产物，来源于大豆 Glycine max，具有抗氧化性和抗癌活性。Desmethylglycitein 在体内直接结合 CDK1 和 CDK2，抑制 CDK1 和 CDK2 活性。Desmethylglycitein 是蛋白激酶 C (PKC)α 的直接抑制剂，抑制正常人皮肤成纤维细胞中的太阳紫外线 (sUV) 诱导的基质金属蛋白酶1 (MMP1)。Desmethylglycitein 以 ATP 竞争方式与细胞质中的 PI3K 结合，抑制 PI3K 和下游信号级联的活性，从而抑制 3T3-L1 前脂肪细胞中的脂肪形成。

靶点

CDK1

CDK2

PKC

体外研究

Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) suppesses anchorage-dependent growth of HCT-116 and DLD1 cells in a dose- and time-dependent manner without cytotoxicity . Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) suppresses CDK1 activity in a dose-dependent manner and inhibits CDK2 activity in HCT-116 cells. Desmethylglycitein (4',6,7-Trihydroxyisoflavone)(0-100 μM; 24-72 hours) induces cell cycle arrest at the S and G2/M phases, the percentage of cells in S phase is higher in the 100 μM 6,7,4′-THIF-treated group, and the same pattern is observed in G2/M phase (29.5% versus 19.1% ) .

Cell Viability Assay

Cell Line:	HCT-116 cells
Concentration:	0, 12.5, 25, 50 or 100 μM
Incubation Time:	24, 48 or 72 hours
Result:	Inhibited anchorage-dependent and -independent growth of HCT-116 cells.

Western Blot Analysis

Cell Line:	HCT-116 and DLD1 cells
Concentration:	0, 25, 50 or 100 μM
Incubation Time:	48 hours
Result:	Inhibited CDK1,CDK2 expression.

Cell Cycle Analysis

Cell Line:	HCT-116 cells
Concentration:	0, 25, 50 or 100 μM
Incubation Time:	24, 48 or 72 hours
Result:	Induces cell cycle arrest of HCT-116 cells at S and G2/M phases.

体内研究

Desmethylglycitein (4',6,7-Trihydroxyisoflavone) (intraperitoneally injection; 5 or 25 mg/kg; once daily; 20 days) suppresses tumor development in mice and serves as an effective anticancer treatment with the potential to inhibit or delay the tumorigenicity of HCT-116 cells in an in vivo system.

Animal Model:	Female athymic nude mice subcutaneously injected with HCT-116 cells
Dosage:	5 or 25 mg/kg
Administration:	Intraperitoneally injection; 5 or 25 mg/kg; once daily; 20 days
Result:	Decreased tumor growth, volume and weight of HCT-116 xenografts.