1834610-73-9

中文名称化合物 T28371

英文名称 Benzenesulfonamide, 3-cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy]-N-1,2,4-thiadiazol-5-yl-

CAS 1834610-73-9

分子式 C35H32F3N7O3S2

分子量 719.8

MOL 文件 1834610-73-9.mol

1834610-73-9 结构式

基本信息物理化学性质应用领域常见问题列表

基本信息

中文别名

化合物 T28371
3-CYANO-4-[2-[2-[(2-PIPERIDIN-4-YLETHYLAMINO)METHYL]PYRIDIN-4-YL]-4-[3-(TRIFLUOROMETHYL)PHENYL]PHENO

英文别名

PF6456384
PF-6456384
PF06456384
PF 6456384
PF 06456384
PF-06456384
3-cyano-4-[2-[2-[(2-piperidin-4-ylethylamino)methyl]pyridin-4-yl]-4-[3-(trifluoromethyl)phenyl]phenoxy]-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
Benzenesulfonamide, 3-cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy]-N-1,2,4-thiadiazol-5-yl-

物理化学性质

沸点789.8±70.0 °C(Predicted)

密度1.46±0.1 g/cm3(Predicted)

酸度系数(pKa)3.30±0.10(Predicted)

应用领域

用途一

PF-06456384 is a highly potent and selective NaV1.7 inhibitor (IC50 NaV1.7 = 0.01 nM). PF-06456384 ultimately showed a lack of preclinical efficacy in a mouse formalin pain model and was not progressed further. PF-06456384 may be used to illustrate the potential to support further in vitro and in vivo evaluation of the translation of NaV1.7 inhibition to the treatment of pain.

常见问题列表

概述

PF-06456384 是一种高效、选择性 NaV1.7 抑制剂，IC50 为 0.01 nM。PF-06456384 具有用于福尔马林疼痛模型研究的潜力。