19767-45-4
中文名称
美司那
英文名称
Mesna
CAS
19767-45-4
EINECS 编号
243-285-9
分子式
C2H5NaO3S2
MDL 编号
MFCD00007535
分子量
164.18
MOL 文件
19767-45-4.mol
更新日期
2025/05/24 23:00:32
19767-45-4 结构式
基本信息
中文别名
2-巯乙基磺酸钠盐美司那
巯乙基磺酸钠
2-巯基乙磺酸钠
巯乙磺酸钠
2-巯基乙烷磺酸钠
美司钠
美法伦
英文别名
2-MERCAPTOETHANESULFONIC ACID SODIUM2-MERCAPTOETHANESULFONIC ACID SODIUM SALT
2-MERCAPTOETHANESULPHONIC ACID SODIUM SALT
COENZYME M
COENZYME M SODIUM SALT
HS-COM NA
MERCAPTOETHANESULFONIC ACID SODIUM SALT
MESNA
MESNA SODIUM SALT
mesnaum
MESNEX
SODIUM 2-MERCAPTOETHANESULFONATE
2-mercaptoethanesulfonic
2-mercaptoethanesulfonicacidmonosodiumsalt
2-mercapto-ethanesulfonicacimonosodiumsalt
mesnum
mistabron
mitexan
mucofluid
uromitexan
所属类别
医药中间体：原料药中间体物理化学性质
外观性状美司那(19767-45-4)为白色结晶
熔点>240°C dec.
储存条件-20°C 冰箱，在惰性气氛下稳定
溶解度Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in cyclohexane
形态neat
颜色白色至灰白色
水溶解性Soluble in water. Also soluble in methanol, DMSO (33 mg/ml) and ethanol (<1 mg/ml).
Merck5909
BRN3657828
稳定性稳定的。与强氧化剂不相容。
安全数据
警示词警告
危险性描述H315-H319-H335
危险品标志Xi
危险类别码R36/37/38
安全说明S26-S36
WGK Germany2
RTECS号KI7968000
海关编码29309090
毒性LD50 in male, female mice, male, female rats (mg/kg): 1887, 2048, 2098, 1683 i.v.; 2005, 2098, 1529, 1251 i.p.; 6102, >7200, 4440, 4679 orally (Brock)
美司钠价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | 44315 | 美司那 2-Mercaptoethanesulfonic acid sodium salt, 98%, analytical standard, Thermo Scientific Chemicals | 19767-45-4 | 5g | 522元 |
| 2025/05/22 | 44315 | 美司那 2-Mercaptoethanesulfonic acid sodium salt, 98%, analytical standard, Thermo Scientific Chemicals | 19767-45-4 | 10g | 888元 |
| 2025/05/22 | 44315 | 美司那 2-Mercaptoethanesulfonic acid sodium salt, 98%, analytical standard, Thermo Scientific Chemicals | 19767-45-4 | 25g | 2134元 |
常见问题列表
生物活性
Mesna 是巯基化合物，用于降低与某些化疗剂相关的出血性膀胱炎的发病率。体外研究
Mesna (1-1000 μM) reduces H 2 O 2 , HOCl and OH• concentrations in a dose-dependent manner, with an IC 50 of 32, 21, and 305 μM, respectively in cell-free experiments.
体内研究
Mesna (150 mg/kg; a single i.p.) protects the rat brain against traumatic injury.
Mesna (200 mg/kg; a single i.p.) attenuates the cisplatin-induced ovarian damages in rats.
| Animal Model: | Adult male Wistar Albino rats (250-350 g) are suffered traumatic brain injury (TBI) |
| Dosage: | 150 mg/kg |
| Administration: | A single i.p. |
| Result: |
Decreased tissue malondialdehyde levels.
Increased the activity of glutathione peroxidase and superoxide dismutase. Decreased the levels of nitric oxide, nitric oxide synthetase and xanthine oxidase. Protected the brain tissues well from injury. |