203737-93-3
基本信息
PST2744
PST 2744
PST-2744
Debio0614
Debio 0614
Istaroxime
PST2744/PST-2744
Istaroxime(PST2744)
PST2744
PST 2744
ISTAROXIME
DEBIO 0614
DEBIO0614
物理化学性质
常见问题列表
IC50: 0.11 μM (Na + ,K + -ATPase)
Istaroxime acting as a positive inotropic compound through the inhibition of the Na + ,K + -ATPase. Istaroxime (PST2744) inhibits the Na + /K + -ATPase activity from dog kidney with an IC 50 value of 0.43 ± 0.15 μM. Inhibition of Na + /K + -ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744.
Istaroxime (PST2744) induces a progressive increase in +dP/dt max throughout the infusion that reaches 80% (ED 80 ) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (ED max ) of 4.88±0.6 mg/kg.