2095489-35-1
中文名称
BRF110
英文名称
BRF110 >=98% (HPLC)
CAS
2095489-35-1
分子式
C22H18F3N3O2
分子量
413.39
MOL 文件
2095489-35-1.mol
2095489-35-1 结构式
应用领域
用途一
BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.