2173232-79-4
2173232-79-4 结构式
物理化学性质
沸点386.2±42.0 °C(Predicted)
密度1.436±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : 6 mg/mL (23.23 mM);Water : < 0.1 mg/mL (insoluble)
酸度系数(pKa)3.04±0.20(Predicted)
形态Solid
颜色Pink to red
2173232-79-4价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-101035 | LOM612 | 2173232-79-4 | 1 mg | 1590元 |
| 2025/05/22 | HY-101035 | 2173232-79-4 LOM612 | 2173232-79-4 | 5mg | 3500元 |
| 2025/05/22 | HY-101035 | 2173232-79-4 LOM612 | 2173232-79-4 | 10mM * 1mLin DMSO | 3850元 |
常见问题列表
生物活性
LOM612 有效对 FOXO 胞质-胞核穿梭进行定位，在 U2fox RELOC 细胞中 EC50 值为 1.5 μM。靶点
EC50: 1.5 μM (FOXO, in U2fox RELOC cells)
体外研究
LOM612 potently activates nuclear translocation of FOXO with an EC 50 value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC 50 value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC 50 , 2.76 μM).