218457-67-1
中文名称
6-[4-(叔丁基)苯氧基]吡啶-3-胺
英文名称
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
CAS
218457-67-1
分子式
C15H18N2O
MDL 编号
MFCD00052647
分子量
242.32
MOL 文件
218457-67-1.mol
更新日期
2024/04/24 11:34:11
218457-67-1 结构式
基本信息
中文别名
6-[4-(叔丁基)苯氧基]吡啶-3-胺 英文别名
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE
BUTTPARK 96\12-100
所属类别
医药中间体：吡啶类化合物
6-[4-(叔丁基)苯氧基]吡啶-3-胺价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/16 | S9719 | 6-[4-(叔丁基)苯氧基]吡啶-3-胺 CB-103 | 218457-67-1 | 5mg | 713.16元 |
| 2024/01/16 | S9719 | CB-103 | 218457-67-1 | 10mM (1mL in DMSO) | 794.43元 |
| 2024/01/16 | S9719 | 6-[4-(叔丁基)苯氧基]吡啶-3-胺 CB-103 | 218457-67-1 | 25mg | 2269.57元 |
常见问题列表
生物活性
CB-103 是一种口服活性的 Notch 转录激活复合物的抑制剂。CB-103 可在果蝇和小鼠中产生Notch功能丧失的表型，并抑制人类乳腺癌和白血病异种移植瘤的生长。靶点
| Target | Value |
|
Notch
() |
体外研究
CB-103 acts as a pan-NOTCH inhibitor by targeting NOTCH transcriptional activation complex.
CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines.
CB-103 exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines.
Cell Viability Assay
| Cell Line: | RPMI 8402, KOPTK1, PANC1, nRas driven melanoma cells |
| Concentration: | 10 μM |
| Incubation Time: | 4 days, 6 days |
| Result: | Caused a significant reduction in their growth potential. |
体内研究
CB-103 inhibits NOTCH dependent cellular processes in mice.
CB-103 blocks in vivo growth of PDX models of T-ALL.
CB-103 (25 mg/kg; i.p./p.o.; 2x daily; for 2 weeks) inhibits growth of GSI/Mab resistant triple negative breast cancer.
CB-103 exhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors.
| Animal Model: | NSG mice, triple negative breast cancer mouse xenograft model |
| Dosage: | 25 mg/kg |
| Administration: | Oral administration/Intraperitoneal injection; 2x daily; for 2 weeks |
| Result: | Inhibited growth of GSI/Mab resistant triple negative breast cancer. |