219832-49-2
219832-49-2 结构式
基本信息
中文别名
SK抑制剂(MP-A08) 英文别名
MP-A084-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-
物理化学性质
沸点717.1±70.0 °C(Predicted)
密度1.28±0.1 g/cm3(Predicted)
溶解度DMF: 33 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 12 mg/ml
酸度系数(pKa)7.88±0.10(Predicted)
形态结晶固体
颜色Light yellow to yellow
219832-49-2价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-19794 | 219832-49-2 MP-A08 | 219832-49-2 | 1mg | 350元 |
| 2025/05/22 | HY-19794 | 219832-49-2 MP-A08 | 219832-49-2 | 5mg | 550元 |
| 2025/05/22 | HY-19794 | 219832-49-2 MP-A08 | 219832-49-2 | 10mg | 900元 |
常见问题列表
生物活性
MP-A08 是一个高度选择性的 ATP 竞争性的 SPHK1 抑制剂。体外研究
MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type.[2]
体内研究
MP-A08 suppresses the growth of human lung tumor xenografts in mice.