22189-32-8
基本信息
壮观霉素盐酸盐
壮观霉素1GM
奇放线霉素盐酸盐
壮观霉素(标准品)
盐酸大观霉素,五水
盐酸壮观霉素五水合物
壮观霉素盐酸盐水合物
大观霉素盐酸盐水合物
盐酸大观霉素五水合物
D00869
U-18409AE
spectogard
Trobicin (tn)
SPECTINOMYCIN HCL
SPECTINOMYCIN 2HCL
Spectinomycin,≥98%
Spectinomycin HCL USP/BP
Spectinomycin dihydrochL
物理化学性质
安全数据
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/01/25 | HY-B1828A | 盐酸大观霉素五水合物 Spectinomycin dihydrochloride pentahydrate | 22189-32-8 | 500mg | 500元 |
2024/01/25 | HY-B1828A | 盐酸大观霉素五水合物 Spectinomycin dihydrochloride pentahydrate | 22189-32-8 | 10mM * 1mLin Water | 550元 |
2024/01/16 | S0584 | 壮观霉素二盐酸盐 五水合物 Spectinomycin Dihydrochloride Pentahydrate | 22189-32-8 | 5g | 120元 |
常见问题列表
Spectinomycin selectively inhibits protein synthesis in cells and in extracts of Escherichia coli . When added to an exponentially growing culture, spectinomycin (50 μg/mL) rapidly and reversibly inhibits growth of Escherichia coli . Amino acid incorporation is slowed immediately but RNA synthesis continued. In extracts of Escherichia coli B, spectinomycin inhibits polypeptide synthesis directed either by endogenous messenger RNA or by MS-2 bacteriophage RNA. Maximum inhibition (70 to 80%) is achieved at 1 μg/mL (3 μM). . Spectinomycin blocks the translocation of peptidyl-tRNAs from the A-site to the P-site by inhibiting the binding of elongation factor G to the ribosome. Spectinomycin interacts specifically with the residues G1064 and 01192 in 16S rRNA and potentially change this molecule into an inactive conformation. Spectinomycin acts as a mixed noncompetitive inhibitor for the td intron RNA with a K i of 7.2 mM. The splicing inhibition by spectinomycin is dependent on pH changes and Mg 2+ concentration, indicating electrostatic interactions with the intron RNA.
Renal excretion is a major elimination pathway for spectinomycin. Following IV administration, approximately 55% of the drug is excreted into the urine in unchanged form. After IV administration of 10 mg/kg spectinomycin shows a peak plasma concentration of 37.8 μg/mL and a systemic exposure (area-under the curve AUC 0-∞ ) of 15.7 μg/mL. Following single dose intramuscular administration, the overall elimination half-life of spectinomycin is 1.2 h in cattle, 1.0 h in sheep, 1.0 h in pigs, 1.65 h in chicken and 1.85 h in humans.