23180-57-6
中文名称
芍药苷
英文名称
Paeoniflorin
CAS
23180-57-6
EINECS 编号
245-476-2
分子式
C23H28O11
MDL 编号
MFCD00869331
分子量
480.46
MOL 文件
23180-57-6.mol
更新日期
2024/04/25 13:34:01
23180-57-6 结构式
基本信息
中文别名
芍药甙芍药苷
英文别名
ACLITAXELNSC 178886
peoniflorin
Delmacinone
Paeony root
Paeoniflorm
PAEONIFLORIN
Paeonia moutan
PAEONIFLORIN(P)
Paeoniflorin std.
Paeoniflorin ,98%
Paeoniflorin P.E.
3aα,5α, 5aα,5bα)]-
Paeoniflorin Extract
White Peony Root P.E.
Paeonia lactiflora P.E.
PAEONIFLORIN 98+% BY HPLC
5-alpha,5a-alpha,5b-alpha))-a-alph
Ramipril (DMF, under registration)
Ranitidine (DMF, under registration)
Levofloxacin DMF (under registration)
Methylprednisolone Acetate, Micronized
PACLITAXEL C13 SOLUTION STD 1.0mg/mL(P)
β-D-Glucopyranoside,5b-[(benzoyloxy)methyl]
Paeoniflorin, froM Paeonia sterniana Fletcher in Journ.
5-methano-1h-3,4-dioxacyclobuta(cd)pentalen-1a(2h)-yl,(1ar-(1a-alpha,2-beta,3
beta-d-glucopyranoside,5b-((benzoyloxy)methyl)tetrahydro-5-hydroxy-2-methyl-2,
tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl,[1aR-(1aα,2β
(2R,6aβ)-3aβ-(Benzoyloxymethyl)-4-(β-D-glucopyranosyloxy)-5-methyl-2α,5α:3α,4α-dimethanohexahydrofuro[2,3-b]furan-2-ol
5beta-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1alpha(2H)-yl-beta-D-glucopyranoside
5beta-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1h-3,4-dioxacyclobuta[cd]pentalen-1alpha(2h)-yl-beta-d-glucopyranoside
(1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl-β-D-glucopyranoside
[(1aR)-5bβ-[(Benzoyloxy)methyl]-3aβ,5,5aβ,5b-tetrahydro-5β-hydroxy-2β-methyl-2,5-methano-3,4-dioxa-1H-cyclobuta[cd]pentalen-1a(2H)-yl]β-D-glucopyranoside
[(1aR)-5bβ-[(Benzoyloxy)methyl]-3aβ,5,5aβ,5b-tetrahydro-5β-hydroxy-2-methyl-2α,5α-methano-3,4-dioxa-1H-cyclobuta[cd]pentalen-1aβ(2H)-yl]β-D-glucopyranoside
β-d-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
beta-d-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aalpha,2beta,3aalpha,5alpha,5aalpha,5balpha)]-
beta.-d-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1a.alpha.,2.beta.,3a.alpha.,5.alpha.,5a.alpha.,5b.alpha.)]
所属类别
生物化工：植物提取物物理化学性质
外观性质白色吸湿性无定形粉末。
外观性状白色结晶，溶于甲醇，来源于牡丹皮、芍药、赤芍。
熔点approximate 124℃ (dec.)
沸点498.51°C (rough estimate)
密度1.3044 (rough estimate)
折射率1.5376 (estimate)
储存条件2-8°C
溶解度甲醇（微溶，超声处理），吡啶（微溶）
酸度系数(pKa)11.52±0.70(Predicted)
形态粉末
颜色白色
InChIKeyYKRGDOXKVOZESV-WRJNSLSBSA-N
安全数据
警示词警告
危险性描述H315-H319-H226
安全说明24/25
WGK Germany3
RTECS号RT1200000
海关编码29389090
毒性LD50 ipr-mus: 9530 mg/kg YKKZAJ 89,879,69
应用领域
用途一
抗心肌缺血、抑制血小板聚集作用；解痉作用；镇痛、镇静作用；抗炎、抗溃疡作用；保肝作用；调节免疫力作用；耐缺氧作用等。临床应用：用于冠心病的治疗；用于老年性疾病，增强体质与免疫功能、抗炎止咳、祛痰平喘等方面，尤其是老年慢性呼吸道疾病的治疗中可作辅助药物。常见问题列表
应用
芍药苷可抗组织细胞氧化应激损伤、抑制星形胶质细胞的激活、增强保护神经，对于纹状体及黑质多巴胺能神经细胞的损伤具有明显的拮抗作用，并可改善运动迟缓，因而可用于治疗阿尔茨海默症、帕金森病、癫痫等脑部疾病。此外，芍药苷还可以抗肿瘤、类风湿关节炎和强直性脊柱炎等自身免疫性疾病。动物实验还证明芍药苷可明显降低血糖含量、对心肺细胞具有重要的保护作用。制备
称取40kg白芍药材，用70％乙醇浸泡过夜，回流提取2次，每次2h，滤过，合并滤液，旋转蒸发至无醇味，调整药液使每1ml药液相当于0.5g生药，备用。称取120kg(湿重)LX38树脂，装入不锈钢柱(300×2300cm)中，柱体积为60L，上样，吸附1h后，先用水300L，10％乙醇300L去除杂质，再用50％乙醇360L洗脱芍药苷和白芍苷，最后用95％乙醇再生树脂，流速为150‑200L/h，将50％乙醇部位浓缩蒸干得2.52kg，其中芍药苷纯度为24％，白芍苷为16％。