245075-84-7

中文名称 2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二

英文名称 2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid)

CAS 245075-84-7

分子式 C35H34Cl2N4O8

分子量 709.57

MOL 文件 245075-84-7.mol

更新日期 2024/07/31 16:57:49

245075-84-7 结构式

基本信息物理化学性质图谱信息 2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二价格(试剂级) 常见问题列表

基本信息

中文别名

2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二
2,2'-((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二基))二(4,1-亚苯基))二( 氧基))双(2-甲基丙酸)

英文别名

LR-90
2,2'-{Methylenebis[(2-chloro-4,1-phenylene)carbamoylimino-4,1-phenyleneoxy]}bis(2-methylpropanoic acid)
2,2-[Methylenebis[(2-chloro-4,1-phenylene)iminocarbonylimino-4,1-phenyleneoxy]]bis[2-methylpropanoic acid]
Propanoic acid, 2,2'-[methylenebis[(2-chloro-4,1-phenylene)iminocarbonylimino-4,1-phenyleneoxy]]bis[2-methyl-
2,2'-((((((methylenebis(2-chloro-4,1-phenylene))bis(azanediyl))bis(carbonyl))bis(azanediyl))bis(4,1-phenylene))bis(oxy))bis(2-methylpropanoic acid)
2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid)

物理化学性质

沸点726.0±60.0 °C(Predicted)

密度1.448±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO : ≥ 100 mg/mL (140.93 mM);Water : < 0.1 mg/mL (insoluble)

酸度系数(pKa)3.01±0.10(Predicted)

形态Solid

颜色White to off-white

图谱信息

2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二(245075-84-7)核磁图(¹HNMR)

2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-76383	2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二 LR-90	245075-84-7	1 mg	420元
2025/05/22	HY-76383	2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二 LR-90	245075-84-7	5mg	1050元
2025/05/22	HY-76383	2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二 LR-90	245075-84-7	10mM * 1mLin DMSO	1639元

常见问题列表

生物活性

LR-90 是晚期糖基化终产物 (advanced glycation end product (AGE)) 抑制剂，能够抑制人单核细胞的炎症反应。LR-90 也可用于糖尿病动物模型研究。

靶点

AGE

体外研究

LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours.
LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours.
LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells.

Cell Viability Assay

Cell Line:	THP-1 cells
Concentration:	0, 25, 50, 100, and 200 μM
Incubation Time:	24 hours
Result:	Showed no cytotoxicity to THP-1 cells.

RT-PCR

Cell Line:	THP-1 cells
Concentration:	0, 25, 50, 100, and 200 μM
Incubation Time:	One hour before S100b addition for 4 hours
Result:	Dose-dependently inhibited mRNA expression of RAGE, MCP-1, COX-2, IP-10, and NOX2 stimulated with S100b.

体内研究

LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats.
LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation.

Animal Model:	Male ZDF rats (13 to 40 weeks)
Dosage:	50 mg/L
Administration:	P.O. for 27 weeks
Result:	Significantly reduced plasma triacylglycerol and cholesterol by ∼55% and ∼30%, respectively. Modestly affected hyperglycaemia and blood pressure. Lowered the body weight.