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24512-63-8

中文名称 京尼平甙
英文名称 Geniposide
CAS 24512-63-8
分子式 C17H24O10
MDL 编号 MFCD00016659
分子量 388.37
MOL 文件 24512-63-8.mol
更新日期 2024/03/28 07:15:20
24512-63-8 结构式 24512-63-8 结构式

基本信息

中文别名
京尼平甙
栀子甙
栀子苷
去羟基栀子甙
枝子苷,京尼平苷
英文别名
GENIPOSIDE
Methyl (1R,2S,6S)-9-(hydroxymethyl)-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
Methyl (1R,2S,6S)-9-(hydroxymethyl)-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-,methyl ester, (1S,4aS,7aS)-
(1S)-1α-(β-D-Glucopyranosyloxy)-1,4aα,5,7aα-tetrahydro-7-hydroxymethylcyclopenta[c]pyran-4-carboxylic acid methyl ester
1α-(β-D-Glucopyranosyloxy)-1,4aα,5,7aα-tetrahydro-7-(hydroxymethyl)cyclopenta[c]pyran-4-carboxylic acid methyl ester
所属类别
生物化工:提取物

物理化学性质

外观性状易溶于水,溶于乙醇,不溶于石油醚。 来源于茜草科植物栀子(Gardenia jasminoides Ellis)果实
熔点160.0 to 164.0 °C
沸点641.4±55.0 °C(Predicted)
密度1.54±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度H2O:≥5mg/mL
酸度系数(pKa)12.80±0.70(Predicted)
形态粉末
颜色白色至米色
检测方法NMR,HPLC
稳定性吸湿性
LogP-1.920 (est)

安全数据

危险性符号(GHS)
GHS06
警示词危险
危险性描述H301
防范说明P301+P310+P330
安全说明24/25
WGK Germany3
海关编码29389090

应用领域

用途1
用于含量测定/鉴定/药理实验等。
药理药效:栀子苷具有缓泻、镇痛、利胆、抗炎、治疗软组织损伤以及抑制胃液分泌和降低胰淀粉酶等作用。
用途2
一种环烯醚萜苷具有多种生物活性,包括神经保护、抗糖尿病、抗增殖和抗氧化活性。栀子苷已被证明是调节Nrf2的易位,并通过PI3K/Akt信号通路上调下游抗氧化蛋白HO-1的表达。胰高血糖素样肽-1(GLP-1)受体也可能在栀子苷诱导的HO-1表达中发挥关键作用。

常见问题列表

简介

京尼平苷又称栀子甙、京尼平甙,外观为棕色至白色结晶性粉末,气微,无苦味,是从茜草科植物栀子的干燥成熟果实中提取的一种环烯醚萜苷类化合物,具有显著的促进胆汁的分泌作用。并能降低血中胆红素,可促进血液中胆红素迅速排泄。

Geniposide.jpg

药理作用

栀子苷对溶血性链球菌和皮肤真菌有抑制作用。有解热、镇痛、镇静、降压及止血作用。泻火除烦,清热利湿,凉血解毒,消肿止痛。主治热病心烦,躁扰不宁,高热烦躁,神昏谵语,黄疸尿赤,热淋涩痛,血热吐衄,目赤肿痛,火毒疮疡;外治扭挫伤痛。

生物活性
Geniposide是Gardenia jasminoides Ellis果实分离得到的一种环烯醚萜苷类。
体外研究

Geniposide exhibits a variety of activities, such as on antithrombosis, anti-inflammation, anti-diabetes, anti-atherosclerosis, antidepression, healing Alzheimer’s disease (AD), anti-hypertension, toxicology, and untoward reaction are summarized. Geniposide markedly declines the production of IL-8, IL-1β and MCP-1 in OGD-induced brain microvascular endothelial cells, the expression of P2Y14 receptor is significantly down-regulated, the phosphorylation of RAF-1, MEK1/2, ERK1/2 are suppressed.

体内研究

Geniposide (200 and 400 mg/kg) significantly decreases the blood glucose, insulin and TG levels in diabetic mice in a dose-dependent manner. This compound also decreases the expression of GP and G6Pase at mRNA and immunoreactive protein levels, as well as enzyme activity. Geniposide (20.0, 40.0, or 80 mg/kg) significantly reverses the excessive, alcohol-induced elevation in both serum ALT/AST and hepatic LPO levels. Geniposide upregulates the expression of heme oxygenase-1 (HO-1) to attenuate the cell apoptosis induced by 3-morpholinosydnonimine hydrochloride (SIN-1) in primary cultured hippocampal neurons. Geniposide inhibits photochemistry-induced thromboembolism model in vivo . Geniposide are very effective depressants on NF-κB by interrupting IκB degradation.

栀子苷价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/01/25HY-N0009栀子苷
Geniposide
24512-63-850mg500元
2024/01/25HY-N0009栀子苷
Geniposide
24512-63-810mM * 1mLin DMSO550元
2024/01/25HY-N0009栀子苷
Geniposide
24512-63-8100mg750元
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