251992-66-2
中文名称
4-[(4-甲基苯基)硫基]噻吩并[2,3-C]吡啶-2-甲酰胺
英文名称
A 205804
CAS
251992-66-2
分子式
C15H12N2OS2
分子量
300.405
MOL 文件
251992-66-2.mol
更新日期
2023/03/20 15:41:21
251992-66-2 结构式
基本信息
中文别名
4-(对甲苯硫基)噻吩并[2,3-C]吡啶-2-甲酰胺4-(P-甲苯基硫)噻吩并[2,3-C]吡啶-2-甲酰胺
4-[(4-甲基苯基)硫基]噻吩并[2,3-C]吡啶-2-甲酰胺
4-(P-甲苯基硫)噻吩并[2,3-C]吡啶-2-甲酰胺
英文别名
CS-635A 205804
A-205804
A 205804
A 205804 USP/EP/BP
A205804
A 205804
A-205804
IKK-16 (IKK Inhibitor VII)
4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide
4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]-
4-[(4-methylphenyl)sulfanyl]thieno[2,3-c]pyridine-2-carboxam...
所属类别
生物化工：Integrin 抑制剂物理化学性质
熔点198-199℃
沸点581.3±45.0 °C(Predicted)
密度1.40±0.1 g/cm3(Predicted)
储存条件Sealed in dry,2-8°C
储存条件Store at +4°C
溶解度≥30 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
酸度系数(pKa)15.12±0.30(Predicted)
形态粉末晶体
颜色白色至橙色再至绿色
常见问题列表
生物活性
A-205804 是抑制 E-selectin 和 ICAM-1 表达的口服有效的，高效、选择性的先导抑制剂，对 E-selectin 和 ICAM-1 作用的 IC50 分别为 20 nM 和 25 nM。A-205804 可用于慢性炎症疾病的研究。靶点
IC50: 20 nM (E-selectin), 25 nM (ICAM-1)
体外研究
A-205804 exhibits Cellular Toxicities for HUVEC with an IC
50
of 152 μM.
A-205804 is an effective inhibitor of cell-cell adhesion in an in vitro flow experiment, demonstrating relevance in a model physiological system.
体内研究
A-205804 (5 mg/kg; p.o.) shows a half-life of 1 hour for rat.
A-205804 (10 mg/kg; p.o.; 3 times per week; for 2 weeks) attenuates the E-selectin expression on the endothelial vascular niche cells in mice.
| Animal Model: | C57BL/6 mice |
| Dosage: | 10 mg/kg |
| Administration: | Oral administration, 3 times per week, for 2 weeks |
| Result: | Efficiently decreased the expression of E-selectin on the endothelial vascular niche cells |
| Animal Model: | Rat |
| Dosage: | 5 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Oral administration |
| Result: | t 1/2 = 1 hour |