25614-03-3
中文名称
溴隐亭
英文名称
Bromocriptine
CAS
25614-03-3
EINECS 编号
247-128-5
分子式
C32H40BrN5O5
MDL 编号
MFCD00870213
分子量
654.59
MOL 文件
25614-03-3.mol
25614-03-3 结构式
基本信息
中文别名
溴麦角环肽溴麦角隐亭
溴麦亭
溴隐亭
溴代麦角隐亭碱
溴隐亭(2-溴-ALPHA-麦角环肽)
2-溴-ALPHA-麦角环肽
2-溴-12'-羟基-5'-ALPHA-异丁基-2'-异丙基麦角胺-3',6',18-三酮
英文别名
BROMOCRIPTINE(5’-alpha)-ropyl)
,6’,18-trione
2-bromo-12’-hydroxy-2’-(1-methylethyl)-5’-alpha-(2-methylpropyl)ergotamin-3’
2-bromo-alpha-ergocryptine
2-bromo-alpha-ergokryptin
2-bromo-alpha-ergokryptine
2-bromo-ergocryptin
2-bromoergocryptine
alpha-bromoergocriptine
bromergocryptine
bromocriptin
bromocryptine
bromoergocriptine
bromoergocryptine
ergotaman-3’,6’,18-trione,2-bromo-12’-hydroxy-2’-(1-methylethyl)-5’-(2-methylp
(5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione
Kripton
Parlodel
Bromoergocryptine mesylate
物理化学性质
外观性状白色结晶性粉末。熔点215-218℃（分解）。
熔点215-218° (dec)
比旋光度D20 -195° (c = 1 in methylene chloride)
沸点891.3±65.0 °C(Predicted)
密度1.2734 (rough estimate)
折射率1.6400 (estimate)
酸度系数(pKa)pKa 4.90±0.05(80% MCS
t = RT) (Uncertain)
水溶解性2.07mg/L(temperature not stated)
安全数据
警示词警告
危险性描述H361-H362-H302
防范说明P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P201-P260-P263-P264-P270-P308+P313
毒性An ergot alkaloid
derivative that exhibits potent dopamine agonist properties, particularly
at D2 dopamine receptors. Bromocriptine, like dopamine,
inhibits prolactin release from the pituitary and so is used in endocrine
disorders, such as hyperprolactinemia. It is also used in the
treatment of Parkinson’s disease. A large “first-pass” effect is seen
with bromocriptine, and peak concentrations occur about 1.5-3 h
after ingestion, with a half-life of about 3 h. Nausea, vomiting, and
orthostatic hypotension are among the acute adverse effects.
Long-term use has been associated with dyskinesias, constipation,
psychoses, digital spasm, and erythromelalgia. The LD50 in rabbits
exceeds 1 g/kg, p.o., and 12 mg/kg, i.v.