256477-09-5
中文名称
NULL
英文名称
UK-371804
CAS
256477-09-5
更新日期
2024/04/14 10:33:05
分子式
C14H16ClN5O4S
分子量
385.83
MOL 文件
256477-09-5.mol
256477-09-5 结构式
基本信息
中文别名
化合物UK371804 英文别名
UK-371804Urokinase inhitibor 1
Urokinase inhibitor 1
UK-371804 (Urokinase inhitibor 1)
所属类别
生物化工：激动剂抑制剂常见问题列表
生物活性
UK-371804是尿嘧啶型纤溶酶原激活物 (uPA) 的抑制剂，Ki值为10 nM。靶点
Ki: 10 nM (uPA)
体外研究
UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC 50 =0.89 μM). UK-371804 has its excellent enzyme potency (K i =10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
体内研究
In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM.