| Identification | Back Directory | [Name]
UK-371804 | [CAS]
256477-09-5 | [Synonyms]
UK-371804
Urokinase inhibitor 1
Urokinase inhitibor 1
UK-371804 (Urokinase inhitibor 1) | [Molecular Formula]
C14H16ClN5O4S | [MDL Number]
MFCD30749185 | [MOL File]
256477-09-5.mol | [Molecular Weight]
385.83 |
| Questions and Answers (Q&A) | Back Directory | [Description]
UK-371804 is a potent and selectiveurokinase-type plasmogen activator (uPA)inhibitor. It has excellent selectivityover tPA, plasmin, Factor IXa and Xa.In vitro, it is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound modelfollowing topical delivery, it is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. It has the potential for the treatment of chronic dermal ulcers.
| [References]
http://www.dcchemicals.com/product_show-UK_371804.html
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.
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| Hazard Information | Back Directory | [Uses]
UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM. | [in vivo]
In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM[1]. | [storage]
Store at -20°C |
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| Company Name: |
Twochem Co.Ltd.
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| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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