| Identification | Back Directory | [Name]
2-8-Angiotensin II, 2-glycine-5-L-isoleucine- | [CAS]
25849-90-5 | [Synonyms]
TRV055
2-8-Angiotensin II, 2-glycine-5-L-isoleucine- | [Molecular Formula]
C42H57N9O9 | [MDL Number]
MFCD34471291 | [MOL File]
25849-90-5.mol | [Molecular Weight]
831.97 |
| Chemical Properties | Back Directory | [Boiling point ]
1273.8±65.0 °C(Predicted) | [density ]
1.296±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.56±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TRV055, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling[1]. | [IC 50]
AT1 Receptor | [References]
[1] Laura M Wingler, et al. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11. DOI:10.1016/j.cell.2018.12.005 |
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