27821-45-0
27821-45-0 结构式
基本信息
尿苷-5′-二磷酸二钠盐，水合
URIDINE 5'-DIPHOSPHATE DISODIUM SALT
URIDINE 5'-DIPHOSPHORIC ACID DISODIUM SALT
5'-UDP-Na2
Uridine 5'-(trihydrogen diphosphate), disodium salt
UDP(URIDINE-5''-DIPHOSPHATE)
URIDINE-5''- DIPHOSPHATE, DISODIUM SALT(UDP.NA2)
Uridine-5'-diphosphoglucose disodium salt
URIDINE-5''-DIPHOSPHATE DISODIUM SALT HYDRATE (UDP)
URIDINE 5''- DIPHOSPHATE DISODIUM SALT (5''-UDP-NA2)
物理化学性质
安全数据
常见问题列表
尿苷-5'-二磷酸二钠盐为有机金属化合物，可用作生化试剂，是P2Y6受体激动剂和GPR105受体抑制剂。
尿苷-5'-二磷酸二钠盐可用作生化试剂，P2Y 受体激动剂。
| Target | Value |
|
P2Y
14
receptor
(Cell-free assay) | 7.28(pEC50) |
|
P2Y
6
receptor
(Cell-free assay) | 300 nM(EC50) |
|
P2Y
6
receptor
(Cell-free assay) | 6.52(pEC50) |
Uridine-5'-diphosphate disodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression.
Uridine-5'-diphosphate disodium salt (100 μM; 3 hours) induces chemokine expression in microglia.
Uridine-5'-diphosphate disodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h.
Uridine-5'-diphosphate disodium salt (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level.
Uridine-5'-diphosphate disodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia.
Uridine-5'-diphosphate disodium salt is a competitive antagonist at the human
P2Y
14
receptor (
pEC
50
=7.28) but not rat P2Y
14
receptor.
UDP-glucose (UDPG; HY-N7032) is a potent P2Y
14
agonist.
RT-PCR
| Cell Line: | Primary microglia |
| Concentration: | 100 μM |
| Incubation Time: | For 15 min |
| Result: | Significantly induced microglial CCL2 and CCL3 mRNA expression. |