28643-80-3

基本信息
尼日利亚菌素钠盐
NIGERICIN(钠盐形式)
尼日利亚菌素,钠盐, 吸水链霉菌
尼日利亚菌素钠盐, 来源于吸水链霉菌
尼日利亚菌素钠盐,来源于链霉菌,吸湿性菌
尼日利亚菌素钠 NIGERICIN SODIUM SALT
Helexin C
Nigerian Sodium
Sodium Nigericin
Nigericin sodiuM sa
Nigericin sodium salt
Nigericin, monosodium salt
Nigericin, sodium salt(1:1)
SODIUM NIGERICIN
NSC-292567
Nigericin sodium salt USP/EP/BP
物理化学性质
安全数据
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2025/05/22 | HY-100381 | 尼日利亚菌素钠盐 Nigericin sodium salt | 28643-80-3 | 5mg | 900元 |
2025/05/22 | HY-100381 | 尼日利亚菌素钠盐 Nigericin sodium salt | 28643-80-3 | 10mg | 1500元 |
2025/05/22 | S6653 | 尼日利亚菌素钠盐 Nigericin sodium salt | 28643-80-3 | 5mg | 794.43元 |
常见问题列表
Target | Value |
Potassium channel
() | |
Hydrogen channel
() | |
Pb 2+
() | |
NLRP3
() |
Nigericin (0.1 µM) decreases inhibits proliferation and clonogenicity of H460 lung cancer cells in a dose dependent manner. Nigericin inhibits migration and invasion of H460 lung cancer cells. Nigericin (0.1-10 nM) has apparently a dual effect on cell volume, that is a shrinking effect at lower Nigericin concentrations and a swelling effect at higher concentrations. Nigericin (0.1-1 nM) significantly decreases cytosolic pH (pHi), and slightly increases the pHi at 5 and 10 nM. Nigericin exhibits higher toxicity on S18 cells than S26 cells, with IC 50 of 2.03±0.55 μM and 4.77±2.35 μM, respectively. Nigericin can selectively kill cancer stem cells in NPC in vitro. Nigericin dramatically reduces the migration ability of S18 and HONE-1 cells. Nigericin exhibits gteat toxicity for the HT29 and SW116 cell line with IC 50 of 12.92±0.25 μmol and 15.86±0.18 μmol. Nigericin also shows a decreased ability to form colonies under anchorage-independent conditions in a standard soft agar assay.
Ngericin (4 mg/kg, i.p.) significantly reduces tumor growth and acts synergistically with the chemotherapeutic agent DDP, as shown by the tumor volumes. Nigericin markedly decreases Bmi-1 in vivo. Overexpression of Bmi-1 partially restores CSC content and metastatic ability of NPC cells under Nigericin treatment. The downregulation of Bmi-1 may be involved in the inhibitory effect of Nigericin on CSCs in NPC.