307538-42-7
中文名称
SMER28
英文名称
SMER 28
CAS
307538-42-7
分子式
C11H10BrN3
分子量
264.121
MOL 文件
307538-42-7.mol
更新日期
2025/07/02 16:10:15
307538-42-7 结构式
基本信息
中文别名
化合物SMER28N-烯丙基-6-溴喹唑啉-4-胺
6-溴-N-2-丙烯-1-基-4-喹唑啉胺
中文同义词:6-溴-N-2-丙烯-1-基-4-喹唑啉胺
英文别名
CS-2308SMER 28
SMER-28
SMER 28
N-Allyl-6-bromoquinazolin-4-amine
SMER28 - CAS 307538-42-7 - Calbiochem
6-BroMo-N-2-propenyl-4-QuinazolinaMine
6-Bromo-N-prop-2-enylquinazolin-4-amine
6-BroMo-N-2-propen-1-yl-4-quinazolinaMine
4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-
所属类别
生物化工：激动剂抑制剂物理化学性质
熔点171-173 °C
沸点391.6±32.0 °C(Predicted)
密度1.520±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度二甲基亚砜：>20mg/mL
酸度系数(pKa)6.12±0.50(Predicted)
形态固体
颜色米色
稳定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
SMER28价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-100200 | SMER28 | 307538-42-7 | 1 mg | 250元 |
| 2025/05/22 | HY-100200 | SMER28 SMER28 | 307538-42-7 | 5mg | 500元 |
| 2025/05/22 | HY-100200 | SMER28 SMER28 | 307538-42-7 | 10mM * 1mLin DMSO | 550元 |
常见问题列表
生物活性
SMER28 是一个调节自噬的、独立于 mTOR 信号通路机制的小分子阳性调节剂，能够阻止β淀粉样蛋白肽的累积。体外研究
SMER28 (5-200 μM; 24 hours) shows a dose dependent decline of cell viability.
Cell Viability Assay
| Cell Line: | MMS1 cells |
| Concentration: | 5, 25, 50, 75, 100, 150, 200 μM |
| Incubation Time: | 24 hours |
| Result: | Showed a dose dependent decline of cell viability. |
体内研究
SMER28 (15-65 mg/kg; i.h.; daily, two days before irradiation and during the three days of irradiation) significantly protects against post-irradiation weight loss and enhances survival of mice at 65 mg/kg.
| Animal Model: | 14 to 16 weeks male mice (Balb/c) |
| Dosage: | 15, 65 mg/kg |
| Administration: | Subcutaneous injection; two days before irradiation and during the three days of irradiation (total 5 days) |
| Result: | Significantly protected against post-irradiation weight loss and enhanced survival of mice at 65 mg/kg. |