31083-55-3
31083-55-3 结构式
基本信息
H2A泛素化抑制剂(PRT4165)
2-(3-吡啶亚甲基)-1,3-茚满二酮
NSC 600157
PRT 4165(NSC 600157)
PRT4165 >=98% (HPLC)
2-(3-Pyridylmethylene)-1,3-indandione
2-(pyridin-3-ylmethylidene)indene-1,3-dione
2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione
1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-
PRT 4165
PRT-4165
NSC600157
NSC-600157
NSC 600157
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-19817 | PRT4165 PRT4165 | 31083-55-3 | 5mg | 416元 |
| 2025/02/08 | HY-19817 | PRT4165 PRT4165 | 31083-55-3 | 10mM * 1mLin DMSO | 457元 |
| 2025/02/08 | HY-19817 | PRT4165 PRT4165 | 31083-55-3 | 10mg | 603元 |
常见问题列表
PRC1
PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation. In vitro E3 ubiquitin ligase activity assays reveal that PRT4165 inhibits both RNF2 and RING 1A, but not RNF8 nor RNF168. In the presence of PRT4165, H2A ubiquitylation can be completely inhibited regardless of whether RING1 or RNF2 contributes the E3 ubiquitin ligase activity. Treatment of cells for 60 min with 50 μM PRT4165 results in a dramatic reduction in total ubiquitylated histone H2A. It is also found that longer exposure of the cells with the PRT4165 (30 and 60 min) leads to increased levels of γ-H2AX in unirradiated cells. PRT4165 inhibits double-strand break (DSB) repair at the 8-h time point compare with mock treated cells. Cells treated with increasing concentrations of PRT4165 show increasing numbers of cells in G 2 /M.