32233-40-2
中文名称
(-)-6beta-羟甲基-7alpha-羟基-顺式-2-氧杂双环[3.3.0]辛-3-酮
英文名称
(-)-Corey lactone diol
CAS
32233-40-2
分子式
C8H12O4
MDL 编号
MFCD00075234
分子量
172.18
MOL 文件
32233-40-2.mol
更新日期
2025/04/28 11:39:48
32233-40-2 结构式
基本信息
中文别名
(-)-6beta-羟甲基-7alpha-羟基-顺式-2-氧杂双环[3.3.0]辛-3-酮(3aR,4S,5R,6aS)-(-)-六氢-5-羟基-4-羟甲基-2H-环戊并[b]呋喃-2-酮
科立内脂二醇
考宁内酯二醇(科尔内酯二醇)
英文别名
(3AR,4S,5R,6AS)-(-)-HEXAHYDRO-5-HYDROXY-4-(HYDROXYMETHYL)-2H-CYCLOPENT A[B]FURAN-2-ONE(3AR,4S,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-(HYDROXYMETHYL)-2H-CYCLOPENTA[B]FURAN-2-ONE
(-)-6BETA-HYDROXYMETHYL-7ALPHA-HYDROXY-CIS-2-OXABICYCLO[3.3.0]OCTAN-3-ONE
(-)-COREY LACTONE
COREY LACTONE DIOL
(3AR,4S,5R,6AS)-(-)-HEXAHYDRO-5-HYDROXY- 4-HOCH2-2H-CYCLOPENTA(B)FURAN-2-ONE, 98%
Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one.
(-)-COREY DIOL (COREY LACTONE)
(-)-6beta-Hydroxymethyl-7alpha-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one
(-)-Corey lactone diol
(-)-COREY LACTONE DIOL,98%
(3AR,4S,5R,6AS)-(-)-HEXAHYDRO-5-HYDROXY-4--2H-CYCLOPENTA(B)FURAN-2-ONE,
(1R)-2β-(Hydroxymethyl)-3α,5α-dihydroxycyclopentane-1α-acetic acid 1,5-lactone
(1S,5R,6S,7R)-7-Hydroxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one
(3aβ,4S,6aβ)-4β-(Hydroxymethyl)-5α-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one
所属类别
分析化学：药典标准品和杂质标准品物理化学性质
熔点117-119 °C(lit.)
沸点262.49°C (rough estimate)
密度1.2104 (rough estimate)
折射率1.4455 (estimate)
储存条件-20°C
溶解度可溶于DMSO（少许）、甲醇（少许）
酸度系数(pKa)14.36±0.40(Predicted)
形态结晶粉末或晶体
颜色白色至米棕色
旋光性 (optical activity)[α]20/D 44°, c = 1.4 in methanol
InChIKeyVYTZWRCSPHQSFX-GBNDHIKLSA-N
常见问题列表
应用
科立内脂二醇是伊洛前列素(I267300)的中间体，对内酰胺酶具有抑制活性。伊洛前列素(I267300)是一种合成的前列环素(PGI2)类似物，用于治疗肺动脉高压(PAH)、硬皮病、雷诺现象和缺血。
用途
科立内脂二醇用作前列腺素类原料药、医药合成中间体等。生物活性
(-)-Corey lactone diol 是 corey aldehyde 的还原形式。化学合成中的砌块。知名试剂公司产品信息
Acros Organics
(-)-6beta-Hydroxymethyl-7alpha-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one, 98%(32233-40-2)Sigma Aldrich
32233-40-2(sigmaaldrich)科立内脂二醇价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/05 | H56119 | (3aR,4S,5R,6aS)-(-)-六氢化-5-羟基-4-羟基甲基-2H-环戊烷[b]呋喃-2-酮, 98% (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-hydroxymethyl-2H-cyclopenta[b]furan-2-one, 98% | 32233-40-2 | 250mg | 409元 |
| 2025/02/05 | H56119 | (3aR,4S,5R,6aS)-(-)-六氢化-5-羟基-4-羟基甲基-2H-环戊烷[b]呋喃-2-酮, 98% (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-hydroxymethyl-2H-cyclopenta[b]furan-2-one, 98% | 32233-40-2 | 1g | 1638元 |
| 2025/02/05 | H1418 | (-)-科里内酯二醇 (-)-Corey Lactone Diol | 32233-40-2 | 200mg | 170元 |