351424-20-9
中文名称
化合物TRPM4-IN-1
英文名称
4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid
CAS
351424-20-9
分子式
C15H11Cl2NO4
分子量
340.16
MOL 文件
351424-20-9.mol
更新日期
2025/07/02 16:10:19
351424-20-9 结构式
基本信息
中文别名
化合物TRPM4-IN-1 英文别名
TRPM4-IN-1TRPM4-IN-5
CBA (TRPM4-IN-5)
TRPM4 inhibitor 5
4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid
4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
Benzoic acid, 4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]-
TRP Channel,Transient receptor potential channels,non-selective,TRPM4IN1,diseases,TRPM4,inhibit,Inhibitor,TRPM-4-IN-1,TRPM4 IN 1,cancer,cation,cardiac,channel,prostate,calcium-activated
化合物TRPM4-IN-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-122605 | 化合物TRPM4-IN-1 TRPM4-IN-1 | 351424-20-9 | 5 mg | 437元 |
| 2025/05/22 | HY-122605 | 化合物TRPM4-IN-1 TRPM4-IN-1 | 351424-20-9 | 10mg | 700元 |
| 2025/05/22 | HY-122605 | 化合物TRPM4-IN-1 TRPM4-IN-1 | 351424-20-9 | 10mM * 1mLin DMSO | 770元 |
常见问题列表
生物活性
TRPM4-IN-1 (CBA) 是一种有效的、选择性的阳离子通道 TRPM4 抑制剂，其 IC50 为 1.5 μM。TRPM4-IN-1 可用于心脏病和前列腺癌的研究。体外研究
TRPM4-IN-1 (compound 5) is a potent and selective inhibitor of TRPM4 current in TRPM4 overexpressed HEK293 cells.
TRPM4-IN-1 reversibly blocks endogenous TRPM4 currents in LNCaP (prostate cancer) cells.
TRPM4-IN-1 (50 μM; Overnight) restores functional expression of A432T, a loss‐of‐expression TRPM4 variant.
Western Blot Analysis
| Cell Line: | HEK293 cells |
| Concentration: | 50 μM |
| Incubation Time: | Overnight |
| Result: | Partial rescued the total and surface expression of A432T. |