40391-99-9
40391-99-9 结构式
基本信息
帕屈膦酸
伊班膦酸杂质5
帕米膦酸及帕米膦酸钠
(3-氨基-1-羟基亚丙基)双膦酸
3-氨基-1-羟基-1,1-丙烷二膦酸
3-氨基-1-羟基丙亚基-1,1-二磷酸
(3-氨基-1-羟基丙烷-1,1-二基)二膦酸
AHPrBP
Panolin
amidronate
Rescriptor
Pamidronicaci
PAMIDRONIC ACID
Iflab-bb F1977-0047
Delavirdine mesylate
Ibandronate Impurity 23
物理化学性质
帕米膦酸二钠(Pamidronate Disodium)：C3H9NO7P2Na2?5H2O。[57248-88-1]。失水温度从77.5℃到239.31℃，失水量为24．65%。
制备方法
帕米膦酸悬浮于水，滴加30%氢氧化钠至Ph值7.2—7.4。-5-5℃冷置析晶，过滤。滤饼加适量蒸馏水，加热溶解，活性炭脱色，冷冻结晶，过滤，室温真空干燥至恒重，得帕米膦酸二钠五水合物，收率78.6%。
常见问题列表
Wnt, β-catenin
Osteosarcoma cell viability decreases significantly in a concentration- and time-dependent manner at pamidronate concentrations ranging from 100 to 1000 μM, most consistently after 48 and 72 hours' exposure. In treated osteosarcoma cells, the lowest percentage cell viability is 34% (detected after 72 hours' exposure to 1000μM pamidronate). Pamidronate disodium inhibits Wnt and β-catenin signaling, which controls osteogenic differentiation in BMMSCs. Wnt3a, a Wnt and β-catenin signaling activator, reverses the negative effects caused by pamidronate disodium to salvage the osteogenic defect in BMMSCs.
Pamidronic acid can significantly inhibit and even reverse early osteoarthritic subchondral bone loss, thus alleviating the process of cartilaginous degeneration. The mechanisms involved may be associated with the upregulation of OPG expression, and downregulation of RANKL, MMP-9 and TLR-4 expression.