| Identification | Back Directory | [Name]
Pamidronic acid | [CAS]
40391-99-9 | [Synonyms]
DLV
AHPrBP
Panolin
Rescriptor
amidronate
Pamidronicaci
PAMIDRONIC ACID
Iflab-bb F1977-0047
Delavirdine mesylate
Ibandronate Impurity 23
Pamidronic acid-d3 major
Pamidronic acid USP/EP/BP
PAMIDRONIC ACID SODIUM SALT
3-AMINO-1-HYDROXY-1,1-PROPANEDIPHOSPHONIC ACID
3-Amino-1-hydroxypropane-1,1-diphosphonic acid
1-Hydroxy-3-aminopropylidenebisphosphonic acid
Propane-1-hydroxy-3-amino-1,1-diphosphonic acid
(3-Amino-1-hydroxypropylidene)diphosphonic acid
(3-amino-1-hydroxypropylidene)bisphosphonic acid
1-Hydroxy-3-aminopropylidenebis(phosphonic acid)
PaMidronic acid(Delavirdine Mesylate,Rescriptor)
(3-Amino-1-hydroxypropylidene)-1,1-bisphosphonate
[2-Aminoethyl(hydroxy)methylene]bisphosphonic acid
(3-amino-1-hydroxypropane-1,1-diyl)diphosphonic acid | [EINECS(EC#)]
254-905-2 | [Molecular Formula]
C3H11NO7P2 | [MDL Number]
MFCD00168777 | [MOL File]
40391-99-9.mol | [Molecular Weight]
235.07 |
| Chemical Properties | Back Directory | [Melting point ]
226-228°C | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
Methanol (Very Slightly, Heated, Sonicated), Water (Slightly, Heated, Sonicated) | [form ]
Solid | [color ]
Light Brown to Beige | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Originator]
Aredia,Novartis,India | [Uses]
A biphosphonate bone resorption inhibitor. | [Uses]
anticancer | [Definition]
ChEBI: Pamidronate is a phosphonoacetic acid. | [Manufacturing Process]
For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.
| [Brand name]
Rescriptor (Agouron). | [Therapeutic Function]
Bone resorption suppressant |
|
| Company Name: |
Ralington Pharma
|
| Tel: |
+91-7948911722 +91-9687771722 |
| Website: |
www.ralingtonpharma.com |
|