459836-30-7

中文名称 [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE

CAS 459836-30-7

分子式 C34H32Br2N6Na4O11P2

分子量 1014.37

MOL 文件 459836-30-7.mol

459836-30-7 结构式

基本信息物理化学性质 [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE价格(试剂级) 常见问题列表

基本信息

英文别名

PEAQX TETRASODIUM HYDRATE
NVP-AAM077 tetrasodiuM hydrate
NVP-AAM 077 tetrasodiuM hydrate
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE

物理化学性质

储存条件-20°C

常见问题列表

生物活性

PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的 NMDA 拮抗剂，其对 hNMDAR 1A 和 hNMDAR 2A 的 IC50 值分别为 270 nM 和 29600 nM。

体外研究

PEAQX (3 µM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent.

体内研究

PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration.
PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F _{3, 73} =4.99).
PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment.

Animal Model:	Timed, day 14 pregnant female Sprague-Dawley rats.
Dosage:	10, 20 or 40 mg/kg.
Administration:	S.C.
Result:	Showed a sensitized locomotor response to PCP challenge on PN28-35.

Animal Model:	Timed, day 14 pregnant female Sprague-Dawley rats.
Dosage:	4 mg/kg.
Administration:	I.P.
Result:	Did not significantly increase locomotor activity in rats treated sub-chronically with PEAQX on PN7, 9 and 11.

Animal Model:	11-week old C57BL/6 mice.
Dosage:	10 mg/kg.
Administration:	IP.
Result:	Reversed the effect of PRE084 (F _3,78 = 10.446, p<0.01).