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4696-76-8

中文名称 卡那霉素 B
英文名称 Bekanamycin
CAS 4696-76-8
分子式 C18H37N5O10
分子量 483.51
MOL 文件 4696-76-8.mol
更新日期 2023/05/30 10:36:05
4696-76-8 结构式 4696-76-8 结构式

基本信息

中文别名
卡那霉素B
卡那霉素杂质B
妥布霉素EP杂质A
卡那霉素 B?, >98%
英文别名
kdm
NK-1006
NK 1006
KANAMYCIN B
Bekanamycin
nebramycinv
kanendomycin
Kanamycin B base
nebramycinfactor5
Bekanamycin, >98%
所属类别
原料药:氨基糖苷类药

物理化学性质

熔点178-182° (dec)
比旋光度D18 +130° (c = 0.5 in water); D21 +114° (c = 0.98 in water)
沸点580.49°C (rough estimate)
密度1.3771 (rough estimate)
折射率1.7600 (estimate)
储存条件Keep in dark place,Inert atmosphere,2-8°C
溶解度酸水溶液(微溶)、甲醇(微溶、加热、超声处理)
酸度系数(pKa)13.07±0.70(Predicted)
形态固体
颜色Crystals
稳定性吸湿性

安全数据

危险性符号(GHS)
GHS07
警示词警告
危险性描述H315; H319; H335
毒性LD50 i.v. in mice: 136 mg/kg (Wakazawa)

应用领域

用途1
为抗生素类药,也是生产硫酸地贝卡星和硫酸阿贝卡星的中间体

上下游产品信息

上游原料
营养肉汤(NB)
下游产品
阿贝卡星
卡那霉素 B价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/01/25HY-B1174卡那霉素 B
Bekanamycin
4696-76-8100mg267元
2024/01/25HY-B1174卡那霉素 B
Bekanamycin
4696-76-810mM * 1mLin Water293元

常见问题列表

生物活性
Bekanamycin (Kanamycin B) 是一种氨基糖苷类抗生素,提取自 Streptomyces kanamyceticus,抑制一系列革兰氏阳性和阴性细菌。
体外研究

Bekanamycin (Kanamycin B) is a precursor for semisynthetic antibiotics such as Arbekacin and Dibekacin and is generally extracted from the broth of S. kanamyceticus .
Bekanamycin (Kanamycin B) in a concentration-dependent fashion reduces reversibly the quantal content of the end-plate potentials while it has no observable effect on the configuration of the extracellularly recorded presynaptic action potential. The reduction in evoked transmitter release produced by Bekanamycin could be antagonized either by increasing the external calcium concentration or by drugs like the aminopyridines which are to greatly enhance transmitter release from motor nerve terminals. Bekanamycin exerts potent inhibitory effects on transmitter release probably by interfering with the influx of calcium that occurs during depolarization of motor nerve terminals.

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