55726-47-1
中文名称
依诺他滨
英文名称
Enocitabine
CAS
55726-47-1
分子式
C31H55N3O6
MDL 编号
MFCD00866294
分子量
565.78
MOL 文件
55726-47-1.mol
更新日期
2023/03/20 15:41:19
55726-47-1 结构式
基本信息
中文别名
依诺他滨山嵛阿糖啶
山嵛阿糖嘧啶
N-[1-[3,4-二羟基-5-(羟甲基)氧杂环戊-2-基]-2-氧代嘧啶-4-基]山嵛酸酰胺
英文别名
BEHENOYLCYTOSINE ARABINOSIDEBH-AC
ENOCITABINE
N-(1-BETA-D-ARABINOFURANOSYL-1,2-DIHYDRO-2-OXO-4-PYRIMIDINYL)DOCOSANAMIDE
NSC-239336
SUNRABIN
n-(1-beta-d-arabinofuranosyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-docosanamid
n(sup4)-behenoyl-1-beta-d-arabinofuranosylcytosine
n(sup4)-behenoylcytosinearabinoside
ENOCITABINE 98.5+% ANTINEOPLASTIC DRUGS
N-(1-B-D-Arabinofuranosyl-1,2-dihydro-2-oxo-4-pyrimidinyl)docosanamide, Behenoylcytosine Arabinoside, BH-AC, NSC-239336, Sunrabin
Docosanamide, N-(1-β-D-arabinofuranosyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-
N4-Behenoyl-1-β-D-arabinofuranosylcytosine
N4-Behenoylcytosine arabinoside
N-[1-[3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]docosanamide
N-[1-[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxo-pyrimidin-4-yl]docosanamide
1-β-D-Arabinofuranosyl-4-(1-oxodocosyl)amino-1,2-dihydropyrimidin-2-one
所属类别
生物化工：激动剂抑制剂物理化学性质
熔点141-142°C
比旋光度D +70° (c = 1 in THF, 22°)
沸点630.87°C (rough estimate)
密度1.0967 (rough estimate)
折射率1.7800 (estimate)
储存条件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度DMSO (Slightly, Heated), Methanol (Slightly, Heated), THF (Slightly, Heated, Soncited)
酸度系数(pKa)10.14±0.20(Predicted)
形态固体
颜色白色至灰白色
常见问题列表
生物活性
Enocitabine 是一种核苷类似物，是一种有效的 DNA 复制抑制剂和 DNA链终止剂。Enocitabine 抑制人巨细胞病毒的复制，具有抗白血病和抗病毒活性。靶点
DNA replication; CMV
体外研究
Enocitabine is resistant to deamination because Enocitabine bears a highly lipophilic group at the 4-amino position of the cytosine moiety of cytarabine.
The combined effects of Pirarubicin and Enocitabine on HeLa S3 human uterine cervix carcinoma and K562 human myelocytic leukemia cells are determined by enhancement of their cytotoxic activities. Enocitabine or etoposide shows synergistic effects on HeLa S3 and K562 cells.
In the presence of Enocitabine, triphosphate forms of the nucleoside analogs are detected in the human cytomegalovirus (HCMV)-infected cells, and synthesis of HCMV DNA is strongly suppressed.