56-94-0
中文名称
地美溴铵
英文名称
Demecarium bromide
CAS
56-94-0
EINECS 编号
200-301-9
分子式
C32H52Br2N4O4
分子量
716.59
MOL 文件
56-94-0.mol
更新日期
2025/05/12 15:47:16
56-94-0 结构式
基本信息
中文别名
3,3'-(1,10-亚癸基双((甲基亚氨)甲酰氧基))双(N,N,N-三甲基苯铵))二溴化物地美溴铵
代麦卡
待买卡农
英文别名
3,3'-(1,10-decanediylbis((methylimino)carbonyloxy))bis(n,n,n-trimethyl-benzenaminium)) dibromidedemecarium bromide
(m-hydroxyphenyl)trimethylammoniumbromidedecamethylenebis(methylcarbamate)
2br
ammonium,(m-hydroxyphenyl)trimethyl-,bromide,decamethylenebis(methylcarbamat
bc48
benzenaminium,3,3’-(1,10-decanediylbis((methylimino)carbonyloxy))bis(n,n,n-t
benzenaminium,3,3’-(1,10-decanediylbis((methylimino)carbonyloxy))bis(n,n,n-tri
decamethylenebis(m-dimethylaminophenyl-n-methylcarbamate)dimethobromide
decamethylenebis(n-methylcarbamicacidm-dimethylaminophenylester)bromomethyl
demekariumbromide
demekastigminebromide
e)(2:1)
frumtosnil
humorsol
n,n’-bis(3-trimethylammoniumphenoxycarbonyl)-n,n’-dimethyldecamethylenediamine
tonilen
tosmicil
tosmilen
tosmilene
所属类别
原料药：拟胆碱药物理化学性质
熔点162-167 °C (decomp)
储存条件-20°C储存
溶解度DMSO:160.0(Max Conc. mg/mL);223.28(Max Conc. mM)
形态固体
颜色白色
InChIKeyYHKBUDZECQDYBR-UHFFFAOYSA-L
SMILESC1(=CC=CC([N+](C)(C)C)=C1)OC(=O)N(C)CCCCCCCCCCN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1.[Br-].[Br-]
常见问题列表
胆碱酯酶抑制药
地美溴铵，西药名。常用剂型为滴眼剂。为胆碱酯酶抑制药。用于缩瞳或用于开角型青光眼。生物活性
Demecarium Bromide (BC-48) 是一种有效的 cholinesterase 抑制剂，Kiapp 值为 0.15 μM。Demecarium Bromide 可用于青光眼的研究。靶点
Kiapp: 0.15 μM (Cholinesterase)
体内研究
Demecarium Bromide (0.125 and 0.5%) causes long-term miosis and decreases intraocular pressure (IOP) in beagles with both normotensive eyes and inherited glaucoma.