61890-25-3
中文名称
1-苯基-2-(吡啶-2-基)乙胺
英文名称
1-phenyl-2-(pyridin-2-yl)ethanamine
CAS
61890-25-3
分子式
C13H14N2
分子量
198.26
MOL 文件
61890-25-3.mol
61890-25-3 结构式
基本信息
中文别名
(RAC)-拉尼西明1-苯基-2-(吡啶-2-基)乙胺
1-苯基-2-(吡啶-2-基)乙烷-1-胺
英文别名
(Rac)-Laniceminerac-Lanicemine 2HCl
1-Phenyl-2-(2-pyridinyl)ethanamine
1-phenyl-2-(pyridin-2-yl)ethanamine
物理化学性质
沸点160 °C(Press: 2 Torr)
密度1.097±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 100 mg/mL (504.39 mM)
酸度系数(pKa)8.29±0.10(Predicted)
形态Liquid
颜色Colorless to light yellow
1-苯基-2-(吡啶-2-基)乙胺价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-108235B | 1-苯基-2-(吡啶-2-基)乙胺 (Rac)-Lanicemine | 61890-25-3 | 5 mg | 312元 |
| 2025/05/22 | HY-108235B | 1-苯基-2-(吡啶-2-基)乙胺 (Rac)-Lanicemine | 61890-25-3 | 10mg | 500元 |
| 2025/05/22 | HY-108235B | 1-苯基-2-(吡啶-2-基)乙胺 (Rac)-Lanicemine | 61890-25-3 | 10mM * 1mLin DMSO | 550元 |
常见问题列表
生物活性
(Rac)-Lanicemine ((Rac)-AZD6765) 是 Lanicemine 的外消旋体。Lanicemine (AZD6765) 是一种低捕获的 NMDA 受体拮抗剂，Ki 为 0.56-2.1 μM。CHO 和爪蟾卵母细胞中，IC50 分别为 4-7 μM 和 6.4 μM。具有抗抑郁作用。靶点
NMDA receptor
体内研究
Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 3, 10 or 30 mg/kg |
| Administration: | Intraperitoneal |
| Result: | Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity. |