6493-05-6
中文名称
己酮可可碱
英文名称
Pentoxifylline
CAS
6493-05-6
EINECS 编号
229-374-5
分子式
C13H18N4O3
MDL 编号
MFCD00063379
分子量
278.31
MOL 文件
6493-05-6.mol
更新日期
2024/04/19 16:16:15
6493-05-6 结构式
基本信息
中文别名
1-(5-氧代己基)可可碱3,7-二氢-3,7-二甲基-1-(5-氧己基)-1H-嘌呤-2,6-二酮
已酮可可豆碱
已酮可可碱
己酮可可碱
英文别名
3,7-DIHYDRO-3,7-DIMETHYL-1-(5-OXOHEXYL)-1H-PURINE-2,6-DIONEPENTOXIFYLLINE
PENTOXYFYLLINE
PENTOXYIFYLLINE
PENTOXYPHYLINE
PTX
TRENTAL
1-(5-Oxohexyl)-3,7-dimethylxanthine
1-(5-oxohexyl)-theobromin
1-(5-Oxohexyl)theobromine
1-(5-oxohexyl)-Theobromine
1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-
3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1h-purine-6-dione
3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)xanthine
Azupentat
BL 191
bl191
Dimethyloxohexylxanthine
所属类别
原料药：周围血管扩张药物理化学性质
外观性状白色针状结晶。熔点105℃。易溶于水、苯、乙醇、氯仿，微溶于乙醇。无臭，味苦。
熔点98-100°C
沸点421.13°C (rough estimate)
密度1.1713 (rough estimate)
折射率1.6000 (estimate)
储存条件Sealed in dry,Room Temperature
溶解度H2O: ≥43 mg/mL
酸度系数(pKa)0.50±0.70(Predicted)
形态solid
颜色white
最大波长(λmax)276nm(lit.)
Merck14,7136
NIST化学物质信息Pentoxifylline(6493-05-6)
己酮可可碱价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-B0715 | 己酮可可碱 Pentoxifylline | 6493-05-6 | 500mg | 400元 |
| 2024/01/25 | HY-B0715 | 己酮可可碱 Pentoxifylline | 6493-05-6 | 10mM * 1mLin DMSO | 500元 |
| 2024/01/25 | HY-B0715 | 己酮可可碱 Pentoxifylline | 6493-05-6 | 1g | 500元 |
常见问题列表
生物活性
Pentoxifylline (BL-191) 是一种血液流变学改善剂。Pentoxifylline 是一种具有口服活性的，非选择性的磷酸二酯酶 (PDE) 抑制剂，具有免疫调节、抗炎、血液流变学改善、抗纤溶和抗增殖作用。Pentoxifylline 可用于研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。靶点
PDE
体外研究
Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner.
Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells.
Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells.
Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase.
Pentoxifylline results in high LC3-II/LC3-ratio.
Cell Autophagy Assay
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 0.1 mM, 1 mM, 5 mM , 10 mM, 50 mM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Inhibited cell proliferation in a dose-dependent manner. |
Apoptosis Analysis
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 12 hours, 24 hours, 36 hours |
| Result: | Induced apoptosis. |
Apoptosis Analysis
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Induced approximately 20-28% of cell autophagy. |
Cell Cycle Analysis
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Induced G0/G1 phase arrest. |
Western Blot Analysis
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 24 hours, 48 hours |
| Result: | Induced high LC3-II/LC3-ratio. |
体内研究
Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and could reduce cognitive impairment.
| Animal Model: | Adult male Wistar rats 12-13-weeks-old (250-300 g) |
| Dosage: | 200 mg/kg |
| Administration: | Intraperitoneal injection, at 1hr before and 3 hr after ischemia |
| Result: | Significantly improved the spatial memory and effects were significant different from those of sham-operated and vehicle groups. |