651005-90-2
中文名称
jedi2
英文名称
2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
CAS
651005-90-2
分子式
C10H8O3S
分子量
208.23
MOL 文件
651005-90-2.mol
更新日期
2023/03/20 15:41:23
651005-90-2 结构式
常见问题列表
生物活性
Jedi2 是一种 Piezo1 活化剂,但不是 Piezo2 活化剂。Jedi2 与小鼠 Piezo1 蛋白结合,Kd 值为 2770 μM。体外研究
Jedi2 evokes Piezo1-mediated Ca
2+
influx. Jedi2 (200 μM) specifically elicits dose-dependent responses in mPiezo1-transfected cells, but not in mPiezo2- or vector-transfected cells .
Jedi2 (1 mM) causes an increase in Ca
2+
in mCherry-positive HEK293T cells transfected with the mPiezo1-mCherry construct, which also responded to Yoda1 (30 μM) .